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The Boxer Lab at the UCSF Mission Bay campus is a state-of-the-art research facility dedicated to advancing medical science. As part of the larger UCSF research complex, this lab supports groundbreaking work in areas like oncology, neuroscience, and immunology. Designed with a sleek, modern aesthetic, the building showcases a fusion of architectural minimalism and high functionality, featuring large windows that flood the interior with natural light, encouraging collaboration and innovation.
The exterior of Boxer Lab is a blend of contemporary materials, with clean lines and a neutral palette. The building’s design incorporates sustainable practices, including energy-efficient windows and thoughtful landscaping, creating an environmentally friendly atmosphere that supports UCSF’s mission of sustainability.
Located in the thriving Mission Bay neighborhood, the lab is strategically positioned at the heart of San Francisco’s biotechnology and research hub. Since its establishment, the Boxer Lab has become a pivotal player in medical research, making strides that influence global healthcare advancements. The surrounding UCSF complex offers additional research facilities, green spaces, and outdoor courtyards for employees to unwind, creating a balanced and inspiring work environment.
For those visiting the UCSF campus, the Boxer Lab stands as a symbol of San Francisco’s commitment to innovation in medical science. The building’s seamless blend of form and function makes it a standout structure in one of the city’s most rapidly developing areas.
Dr. Rachel Sherman is Principal Deputy Commissioner of Food and Drugs at the U.S. Food and Drug Administration (FDA), where she oversees medical programs and initiatives that are cross cutting and clinical, scientific, regulatory, or operational. As the Commissioner’s most senior policy advisor, Dr. Sherman provides council on medical product development and regulatory issues and oversees on his behalf high-priority programs and offices, including the Office of Medical Products and Tobacco, Office of Operations, Office of the Chief Scientist, and the Oncology Center of Excellence. Key areas of current focus include modernizing the agency’s organizational structure, streamlining review of combination products, and developing policies around orphan product development, patient engagement, use of real world evidence, prescription drug promotion and patient information, use of innovative trial designs, and standards for evidence development. Learn more about Dr. Sherman: www.fda.gov/about-fda/fda-organization/meet-rachel-sherma...
This photo is free of all copyright restrictions and available for use and redistribution without permission. Credit to the U.S. Food and Drug Administration is appreciated but not required. For more privacy and use information visit: www.flickr.com/people/fdaphotos/
FDA photo by Cathy Brown
CT scans are an important tool in patient diagnosis and treatment. Since 2014, this CT scanner in the NIH Clinical Center has provided patients and researchers with better quality scans, faster run times, and a lower radiation dose.
Credit: National Institutes of Health
Located in the heart of San Francisco’s vibrant Mission Bay district, the UCSF Mission Bay campus stands as a beacon of cutting-edge healthcare and research. Opened in 2003, this campus was designed to foster interdisciplinary collaboration, integrating academia, research, and clinical care into one cohesive environment. The modern architecture is instantly recognizable, with sleek glass façades reflecting the ever-changing Bay Area sky, a symbol of transparency and forward-thinking design. The building in the attached photo showcases the architectural ambition of the campus, with its striking angular glass surfaces designed to catch and manipulate light. This specific structure houses a variety of UCSF’s top-tier programs in health sciences, fostering breakthrough discoveries.
Beyond its architectural significance, UCSF Mission Bay holds an important place in the local community and on a global scale. The expansive campus spans over 57 acres and includes several buildings, labs, and clinics. It is particularly well known for the UCSF Medical Center at Mission Bay, a state-of-the-art hospital that opened in 2015, specializing in pediatric, cancer, and women’s health services.
Insiders to the city often tout UCSF Mission Bay as one of San Francisco’s architectural gems. The integration of natural landscaping around its structures creates a serene environment conducive to both research and patient care. Proximity to local parks and waterfront areas only enhances its appeal. Whether you're exploring the health sciences or simply admiring its contemporary design, UCSF Mission Bay is a landmark of modern achievement in architecture, medicine, and community engagement.
Niemann-Pick disease type C1, a lipid storage disorder, as seen in a mouse cerebellum.
An experimental drug appears to slow the progression of Niemann-Pick disease type C1 (NPC1), a fatal neurological disease, according to results of a clinical study led by researchers at the National Institutes of Health.
More information: www.nih.gov/news-events/news-releases/experimental-treatm...
Credit: National Institute of Child Health and Human Development, NIH
NIH researchers found that our brains may store memories in neuronal firing patterns that are replayed fractions of a second before remembering.
Read more: www.nih.gov/news-events/news-releases/scientists-monitore...
Credit: National Institute of Neurological Disorders and Stroke, NIH
A new clinical study led by the National Eye Institute (NEI), part of the National Institutes of Health, will follow 500 people over five years to learn more about the natural history of early age-related macular degeneration (AMD). By using the latest technologies to visualize structures within the eye and measure their function, researchers hope to identify biomarkers of disease progression, well before it advances to late-stage disease and causes vision loss. AMD is the leading cause of vision impairment and blindness among people age 50 and older in the United States.
More information: www.nih.gov/news-events/news-releases/nih-launches-intern...
Credit: National Eye Institute
In 2015, Hospital Epidemiologist Dr. Tara Palmore ‘dons’ personal protective equipment (PPE) in the Special Clinical Studies Unit (SCSU). The SCSU is an inpatient unit designed with state-of-the-art infrastructure that allows for isolation capabilities and infection control while patients participate in clinical research studies.
Photo Credit: Hilary Schwab
NIH experts care for a patient in Interventional Radiology. Interventional radiology is a minimally invasive medical specialty that provides image-guided diagnosis and treatment of diseases in every organ system and is crucial to care and treatment of patients at the NIH Clinical Center.
Credit: National Institutes of Health
The anti-cancer drug pembrolizumab has shown promise in slowing or stopping the progression of progressive multifocal leukoencephalopathy (PML), a typically fatal infection of the brain caused by the JC virus (JCV). This finding comes from a small-scale study by scientists at National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.
Read more: www.nih.gov/news-events/news-releases/releasing-immune-sy...
Credit: Daniel S. Reich, National Institute of Neurological Disorders and Stroke, NIH
30/06/2023. Cambridge, United Kingdom. Prime Minister Rishi Sunak meets staff as he visits Addenbrooke’s Hospital. Picture by Simon Dawson / No 10 Downing Street
The NIH's Clinical Center, located on the NIH campus in Bethesda, MD, is more than three million square feet.
Credit: National Institutes of Health
Dr. Marta Čeko of the NCCIH Division of Intramural Research prepares a participant for a CAT scan in an NCCIH study on pain.
NCCIH’s Portal on Pain Information: nccih.nih.gov/health/pain
Credit: National Center for Complementary and Integrative Health, National Institutes of Health
An x-ray image of a patient with melorheostosis shows excess bone formation, likened to dripping candle wax.
Researchers at the National Institutes of Health worked with 15 patients from around the world to uncover a genetic basis of the rare bone disease.
The results, appearing in Nature Communications, offer potential treatment targets for this rare disease, provide important clues about bone development, and may lead to insights about fracture healing and osteoporosis.
Read more: www.nih.gov/news-events/news-releases/nih-researchers-cra...
Credit: National Institutes of Health
Brain scans of healthy volunteers have shown that human brains may drain waste through lymphatic vessels, the body’s sewer system.
More information: www.nih.gov/news-events/news-releases/nih-researchers-unc...
Credit: Reich Lab, National Institute of Neurological Disorders and Stroke, NIH
Once the patient's skin has been treated with topical medicine and moisturizer, it is time to apply the wet wrap, which keeps the creams in contact with the skin. Here, to cover the majority of the body, the patient is dressed in his pajamas, which also have been soaked in warm water. The rest of his skin is covered by wet gauze. The patient then dresses in dry clothes and wraps up in blankets to stay warm. The wrap is worn for about two hours. The wrap may also be worn overnight, depending on the severity of the condition.
Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health
Description: Technician checks MRI machine with patient
Credit: National Institute of Mental Health, National Institutes of Health
National Institutes of Health researchers, along with researchers at Siemens, have developed a high-performance, low magnetic-field MRI system that vastly improves image quality of the lungs and other internal structures of the human body. The new system is more compatible with interventional devices that could greatly enhance image-guided procedures that diagnose and treat disease, and the system makes medical imaging more affordable and accessible for patients.
The low-field MRI system may also be safer for patients with pacemakers or defibrillators, quieter, and easier to maintain and install. The study, funded by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, appeared in the journal Radiology on October 1, 2019.
Read more: www.nih.gov/news-events/news-releases/nih-researchers-dev...
Credit: Campbell-Washburn A E, Ramasawmy R, Restivo M C, et al.
Findings from a phase 2 clinical trial show that the drug selumetinib improves outcomes for children with the genetic disorder neurofibromatosis type 1 (NF1). In the trial, selumetinib shrank the inoperable tumors that develop with NF1 called plexiform neurofibromas, and children experienced reduced pain, improved function, and better overall quality of life after receiving the treatment.
Read more: www.nih.gov/news-events/news-releases/nih-trial-selumetin...
In this image: Dr. Brigitte Widemann with Travis Carpenter, who received selumetinib for NF1 at NIH.
Credit: National Cancer Institute, NIH
Photon CT scan image of a research subject at the NIH. Greater amounts of iodine contrast are shown in brighter, yellow colors.
More information: www.nih.gov/news-events/news-releases/nih-uses-photon-cou...
Credit: Clinical Center, National Institutes of Health
In this image: Mr. Curtis Minor, 58 year old AA Male who is taking part in the SPRINT study at Downtown Health Plaza with Miriam Baird, RN.
A major NIH-funded clinical trial has discovered nuanced evidence linking brain and vascular health.
Learn more: www.nih.gov/news-events/news-releases/does-intensive-bloo...
Credit: Wake Forest School of Medicine
NIH support from: NIA, NHLBI, NIDDK and NINDS
In spring, the foliage around the NIH Clinical Center blooms. Currently there are about 1,600 clinical research studies in progress at the here. Medical discoveries made here include: development of chemotherapy for cancer, the first use of an immunotoxin to treat a malignancy (hairy cell leukemia) and the first gene therapy.
For women in resource-poor settings, taking a certain daily nutritional supplement before conception or in early pregnancy may provide enough of a boost to improve growth of the fetus, according to an NIH-funded study. The inexpensive supplement consists of dried skimmed milk, soybean and peanut extract blended into a peanut butter-like consistency. Weighing less than an ounce, the supplement is fortified with essential vitamins and minerals and provides protein and fatty acids often lacking in the women’s diets. In this image, a participant in the trial prepares the supplement.
Read more: www.nih.gov/news-events/news-releases/inexpensive-supplem...
Credit: Nancy Krebs University of Colorado Anschutz Medical Campus, Aurora, CO
NIH support from: Eunice Kennedy Shriver National Institute of Child Health and Human Development
A healthy volunteer receives the NIAID Zika virus investigational DNA vaccine as part of an early-stage trial to test the vaccine's safety and immunogenicity. This is the first administration of this vaccine in a human.
Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health
In a new study from the National Cancer Institute (NCI), part of the National Institutes of Health, researchers found a higher than expected prevalence of cancer at baseline screening in individuals with Li-Fraumeni syndrome (LFS), a rare inherited disorder that leads to a higher risk of developing certain cancers. The research demonstrates the feasibility of a new, comprehensive cancer screening protocol for this high-risk population.
This image is part of a representative image of a whole body MRI of an LFS patient. Arrow denotes lesion found to be lung adenocarcinoma.
More information: www.nih.gov/news-events/news-releases/nci-study-shows-fea...
Credit: National Cancer Institute, NIH
A clinical trial has begun to examine the safety and use of two HIV prevention tools—oral pre-exposure prophylaxis (PrEP) and a vaginal ring—in adolescent girls and young women in southern Africa. Funded by the National Institutes of Health, the trial is designed to contribute to the delivery of safe, effective and desirable choices of HIV prevention methods for adolescent girls and young women, who are disproportionately affected by the HIV epidemic.
Learn more: www.nih.gov/news-events/news-releases/study-prep-vaginal-...
Credit: National Institute of Allergy and Infectious Diseases/NIH
Hanna Kim, M.D., M.S., is a Lawrence Shulman scholar in the NIAMS Pediatric Translational Research Branch. Her research seeks to ascertain the pathogenesis (the biological mechanisms leading to a disease) for juvenile dermatomyositis, an inflammatory muscle disease. The results of these studies may lead to new biomarkers and potential treatments for the disease. In this photo, she is setting up for gene expression analysis from RNA.
Credit: Richard Clark
Researchers from the National Institutes of Health Kevin D. Hall, Ph.D., center, and Stephanie Chung, M.B.B.S., right, talk with a study participant at the NIH Clinical Center.
People eating ultra-processed foods ate more calories and gained more weight than when they ate a minimally processed diet, according to results from a National Institutes of Health study. The difference occurred even though meals provided to the volunteers in both the ultra-processed and minimally processed diets had the same number of calories and macronutrients.
Read more: www.nih.gov/news-events/news-releases/nih-study-finds-hea...
Credit: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/NIH
NIAMS researchers Raphaela T. Goldbach-Mansky, M.D., M.H.S. (left) and Nicole Plass, R.N., M.P.A., U.S. Public Health Service, with a DIRA patient. NIAMS’ research has led to the identification and successful treatment of DIRA (deficiency of the interleukin-1 receptor antagonist), a genetic autoinflammatory disorder in children.
Credit: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health
Radiology and Imaging Sciences technologist Rob Evers (left) talks to a patient before a scan in the fully integrated whole-body simultaneous PET/MRI device. The Clinical Center acquired one of the first of these machines; it will contribute to study of traumatic brain injury (TBI) and related post-traumatic stress disorder.
Credit: Clinical Center, National Institutes of Health
Dr. Emily Chew of the National Eye Institute examines a patient’s eyes.
An NIH funded study underscores the benefits to eye health of controlling diabetes.
More information: www.nih.gov/news-events/news-releases/eye-study-underscor...
Credit: National Eye Institute, National Institutes of Health
The NIH Clinical Center’s Rehabilitation Medicine Department presented a virtual reality demonstration for NIH researchers. The benefits of immersing patients with rare and undiagnosed diseases into carefully controlled, computer-generated environments is being studied at the Clinical Center.
Credit: National Institutes of Health
In late 2014, the Clinical Center, along with the Office of Research and Facilities, completed the installation of a large autoclave, or pressure chamber, used to sterilize equipment.
The autoclave, accompanied by two smaller autoclaves installed in September, serves the Special Clinical Studies Unit (SCSU). The SCSU is an inpatient unit designed with a state-of-the-art infrastructure that allows for isolation capabilities and infection control while patients participate in clinical research studies. Being in close proximity to the high containment unit, used recently to treat patients exposed to or diagnosed with Ebola, allows for the processing of waste on-site. All waste is steam sterilized at temperatures of at least 250 degrees Fahrenheit under pressure for no less than an hour.
Credit: Clinical Center, NIH
Hanna Kim, M.D., M.S., is a Lawrence Shulman scholar in the NIAMS Pediatric Translational Research Branch. Her research seeks to ascertain the pathogenesis (the biological mechanisms leading to a disease) for juvenile dermatomyositis, an inflammatory muscle disease. The results of these studies may lead to new biomarkers and potential treatments for the disease. In this photo, she is examining a pediatric patient in the NIH Clinical Center.
Credit: Richard Clark, NIAMS Office of Science Policy, Planning and Communications, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health
(From l to r) Rachel Daniels, Alani Daniels and Dr. Elaine Cochran, NIH Clinical Center. Alani has congenital generalized lipodystrophy. Alani’s body is unable to store fat under her skin, and any fat she does take in can connect to organs such as the heart and liver, causing health complications.
Photo credit: Courtesy of Rachel Daniels
National Center for Advancing Translational Sciences (NCATS)
National Institutes of Health
Eczema, also known as atopic dermatitis, is a chronic condition that causes the skin to become extremely itchy. Persistent scratching can lead to redness, blisters that “weep” clear fluid, bleeding, and crusting of certain areas of the skin. People with eczema also can be more susceptible to bacterial, viral, and fungal skin infections.
People suffering from severe eczema come to NIH as part of a research program to better understand, prevent, and treat the disease. NIAID scientists evaluate each case and may decide to use wet wrap therapy to bring the condition under control. The researchers also provide training on home-based skin care to help patients and/or their caregivers properly manage flare-ups once they leave the hospital.
Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health
David Harris has Vici syndrome, a multisystem congenital disorder characterized by agenesis (failure to develop) of the part of the brain called the corpus callosum. Symptoms can include cataracts, hypopigmentation of the eyes and hair, cardiomyopathy and combined immunodeficiency.
Photo credit: Courtesy of Michael and Rachel Harris.
National Center for Advancing Translational Sciences (NCATS)
National Institutes of Health
(From l to r) Megan and Shannon O’Boyle. Shannon O’Boyle suffers from Phelan-McDermid syndrome, a rare condition that can cause autism, epilepsy and intellectual disabilities.
Photo Credit: Courtesy of Megan O’Boyle.
National Center for Advancing Translational Sciences (NCATS)
National Institutes of Health
Ashley Appell is one of over 25 million Americans living with a rare disease. Ashley was born with albinism, which leads to diminished pigment in the skin, hair, and eyes and a visual impairment. When she started to walk her mother became concerned about continuous bruising, and Ashley was found to have a bleeding problem due to abnormal platelets. She was diagnosed with Hermansky Pudlak syndrome (HPS), a form of albinism which includes other health problems such as colitis and pulmonary fibrosis. Ashley has been part of an HPS research study since childhood. As a young adult she takes every opportunity to educate and advocate for HPS and rare diseases, including displaying her singing skills at events and taking part in the documentary Rare. Ashley’s mother, Donna Appell is cofounder of the HPS Network.
For more information visit www.fda.gov/orphan.
30/06/2023. Cambridge, United Kingdom. Prime Minister Rishi Sunak meets staff as he visits Addenbrooke’s Hospital. Picture by Simon Dawson / No 10 Downing Street
It’s a real challenge to treat a patient with relapsed cancer, because the cancer has outsmarted initial treatment and has become more resistant, says Steven Dubois, MD, assistant professor of pediatrics at UCSF’s School of Medicine and a specialist in childhood cancers.
Now, DuBois and his colleagues at the UCSF Helen Diller Family Comprehensive Cancer Center have access to a vastly expanded array of potential resources in their battle against childhood cancers. Keep reading www.ucsf.edu/news/2012/05/11985/ucsf-clinicians-get-new-a...
Photo by Cindy Chew
Patients who arrive to the NIH Clinical Center during business hours, Monday through Friday from 7 am to 5 pm are greeted by a member of the Hospitality team inside the main entrance. As a research facility, only patients with a precise kind or stage of illness under investigation are admitted for treatment. There are no labor and delivery services and no other services common to community hospitals.
30/06/2023. Cambridge, United Kingdom. Prime Minister Rishi Sunak meets staff as he visits Addenbrooke’s Hospital. Picture by Simon Dawson / No 10 Downing Street
30/06/2023. Cambridge, United Kingdom. Prime Minister Rishi Sunak meets staff as he visits Addenbrooke’s Hospital. Picture by Simon Dawson / No 10 Downing Street
At any time and from anywhere, students and residents can now learn how to write a professional-level, peer-reviewed research protocol, from idea to shopping for funding. Keep reading at ctsi.ucsf.edu/news/about-ctsi/improving-clinical-research...
30/06/2023. Cambridge, United Kingdom. Prime Minister Rishi Sunak meets staff as he visits Addenbrooke’s Hospital. Picture by Simon Dawson / No 10 Downing Street
30/06/2023. Cambridge, United Kingdom. Prime Minister Rishi Sunak meets staff as he visits Addenbrooke’s Hospital. Picture by Simon Dawson / No 10 Downing Street
Cavities are the number one infectious disease in children in the U.S. Zhan is an emerging leader in the use of xylitol, a naturally occurring sugar alcohol, to prevent tooth decay in children. Read the story ctsi.ucsf.edu/news/about-ctsi/applying-science-prevent-ch...
Learn more about Ling's research at UCSF Profiles profiles.ucsf.edu/ProfileDetails.aspx?From=SE&Person=...