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@Pathology2018 #histopathology #cytopathology #Liverpathology #Molecularpath #dermpath #pulmonarypath #Diagnosticspath #perinatalpath #experimentalpath #autopsypath #e_pathology #plant #renalpath #immunopath #Digitalpath #nephrpopath #neuropath #SLPeeps
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Cohort Study Indicates That Selenium May Be Protective
Against Advanced Prostate Cancer
Higher toenail selenium levels were associated with a reduced risk for advanced prostate cancer.
Toenail selenium levels reflect long-term selenium intake.
Further studies in low-selenium populations are required.
WASHINGTON, D.C. — A greater level of toenail selenium was associated with a significant decrease in the risk for advanced prostate cancer, according to data presented at the AACR Annual Meeting 2013, held in Washington, D.C., April 6-10.
“This could mean, based on our data and based on data from other studies, that selenium is a modifiable risk factor of advanced, clinically relevant prostate cancer,” said Milan S. Geybels, M.Sc., a doctoral candidate in cancer epidemiology at Maastricht University, in Maastricht, the Netherlands.
The Netherlands Cohort Study on diet and cancer is a prospective cohort study that includes 58,279 men who were aged 55 to 69 years at entry in September 1986. Geybels and colleagues analyzed data from 898 men who were diagnosed with advanced prostate cancer during 17.3 years of follow-up of the cohort.
According to Geybels, previous studies investigating the association between selenium levels and prostate cancer have yielded varying results. One large clinical trial showed that selenium supplementation had no protective effect, while several prospective, observational studies indicated that higher levels of selenium were associated with a reduced prostate cancer risk, especially for advanced prostate cancer.
“Our study is interesting because we specifically investigated men with advanced prostate cancer, a type of prostate cancer associated with a poorer prognosis,” Geybels said. “Also, while most of the prior research, including the large clinical trial, involved men with moderate-to-high selenium levels, men in The Netherlands Cohort Study have selenium levels that range from low to moderate. This is important because low selenium is expected to be related to a higher disease risk.”
He and his colleagues chose toenail selenium as the study biomarker because it reflects long-term exposure, as opposed to blood, which is best for monitoring recent selenium exposures.
The data revealed that greater levels of toenail selenium were associated with a substantially reduced risk for advanced prostate cancer. Men with the highest toenail selenium levels had a more than 60 percent lower risk for advanced prostate cancer compared with men with the lowest toenail selenium levels.
“Our findings need to be replicated in further prospective studies, with an extended follow-up for the assessment of incident advanced prostate cancer, and with a wide range of toenail selenium that includes low selenium levels,” Geybels said. “If our results can be confirmed, a prevention trial of selenium and prostate cancer in a low-selenium population may be justified.”
# # #
Abstract Number: 3613
Presenter: Milan S. Geybels, M.Sc.
Title: Toenail selenium is associated with a decreased risk of advanced prostate cancer
Authors: Milan S. Geybels1, Bas A.J. Verhage1, Frederik J. van Schooten1, Alexandra Goldbohm2, Piet A. van den Brandt1. 1Maastricht University, Maastricht, Netherlands; 2TNO, Netherlands
Introduction: Selenium status has been associated with a reduced risk of total prostate cancer (PCa) and there is evidence that the association is more pronounced for advanced, clinically relevant PCa. This association, however, has been studied over a relatively narrow range of selenium status and data from low-selenium populations are missing. Most prior studies of selenium status and PCa have used plasma/serum selenium, which reflects recent selenium intake, and few studies have used toenail selenium, which reflects longer exposure time windows.
Methods: We studied the association of toenail selenium and advanced PCa risk in the Netherlands Cohort study, which includes 58,279 men aged 55 to 69 years. The study has a case-cohort design; a random subcohort was sampled at baseline in 1986 and incident advanced (stage III/IV) PCa cases were identified during 17.3 years of follow-up. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models.
Results: The study population included 898 advanced PCa cases and 1,203 subcohort members. The average toenail selenium concentration among subcohort members was 0.549 μg/g (standard deviation: 0.128). Toenail selenium was associated with a reduced risk of advanced PCa and adjusted HRs for increasing quintiles of toenail selenium were 1.00 (reference), 0.69 (95% CI: 0.52, 0.90), 0.45 (95% CI: 0.34, 0.60), 0.32 (95% CI: 0.24, 0.44), and 0.24 (95% CI: 0.17, 0.33) (P for trend 6 to 12 years, and >12 years of follow-up were 0.91 (95% CI: 0.85, 0.98), 0.85 (95% CI: 0.75, 0.96), and 0.77 (95% CI: 0.71, 0.84), respectively.
Conclusion: Toenail selenium was associated with a substantial decrease in risk of advanced PCa, particularly during later follow-up. If our results can be confirmed, a prevention trial of selenium and PCa in a low-selenium population may be justified. Selenium exerts important biological functions through its presence in selenoproteins and genetic variation in the major selenoproteins glutathione peroxidase 1 (GPX1) and selenoprotein P (SEPP1) has been associated with the risk of PCa. In a next analysis, in the same population, we will study the association of common variation in GPX1 and SEPP1 with advanced PCa risk, and we will evaluate SNP-selenium interactions.
@Pathology2018
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Oct 08-08,2018 #edinburgh #scotland
Renowned speaker Opportunity at CME Pathology-2018
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Why attend 17th International Conference on Pathology ?🤔
Who should attend ? 🤔🤔
What are the Scientific Tracks in 17th International Conference on Pathology
What Places can we attend in Edinburgh, Scotland ?🤔🤔
Who are the Renowned Speakers ? 🤔🤔 Zahra Maleki
Confused ??😵
Have a look to know about @Pathology2018
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@Pathology2018
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DNA Genotyping and Sequencing. A technician at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG), washes arrays used in genome-wide association studies (GWAS). These studies search the genome for small variations, called single nucleotide polymorphisms or SNPs, that occur more frequently in people with a particular disease than in people without the disease.
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#Pathology #Callforabstracts on all aspects of #Cancer #Epidemiology and the application of #Cancer #Epidemiologic methods, but abstracts on other topics in #Cancer #Epidemiology are also welcome.
#Pathology2018 #Edinburgh #Scotland Oct 08-09, 2018
#Invitation 17th #International #Conference on #pathology & #Cancer #epidemiology #pathologists #doctors #YRF #Students #exhibitors #sponsors
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DNA Genotyping and Sequencing
High-throughput DNA processing is enabled by automated liquid-handling robots at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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What is Brain Cancer?
A brain tumor, known as an intracranial tumor, central nervous system (CNS) tumors represent a group of diseases that have in common the abnormal development of mass lesions in the brain, spinal cord or its coverings.
How Brain Cancer affected population?
Brain Cancer Epidemiology in 2020-
•In the United States, the incidence of Brain Tumors was 13,534 in males and 9,522 in females.
•The total incident population of Primary Brain Tumors in the 7M was estimated to be 60,246.
•Japan had 8,275 incident cases of Primary Brain Tumors.
Brain Cancer Market Outlook
The Brain Tumors market size in the 7MM was estimated to be USD 2,089.4 Million in 2020, which is expected to show a positive growth at a CAGR of 4.19% during the study period 2018–2030.
For report, click here @ www.delveinsight.com/report-store/brain-cancer-market
Brain tumors, specifically HGGs are very difficult tumors to treat due to the problems in completely removing the tumor and their resistance to radiotherapy and chemotherapy. As there is no ideal treatment, therefore it is quite challenging as some cells may respond well to certain therapies, while others may not be affected at all. Because of this, the treatment plan for the indication may combine several approaches. The treatment often comprises a combination of several therapies, including surgery, chemotherapy, radiation, or stereotactic radiosurgery followed by the additional/adjuvant treatments, such as chemotherapy or radiation therapy, after surgery. Treatment is palliative and may include surgery, radiation therapy and/or chemotherapy.
The best treatment options for each person depends on many factors like the size and location of the tumor, the extent to which the tumor has grown into the surrounding normal brain tissues, and the affected person’s age and overall health.
What are the Brain Cancer market drivers?
Robust pipeline activity, upcoming launches and approval, increasing awareness programs, increase in reimbursement and insurance policies, improved treatment deliverance are the Brain Cancer market drivers.
What are the Brain Cancer market barriers?
Use of off-label therapies and generics, high-treatment costs, high recurrence rate, multiple treatment challenges are the brain cancer market barriers.
Which are the leading companies in Brain Cancer market?
The Brain Cancer market dynamics is anticipated to change in the coming years owing to the improvement in the diagnosis methodologies, raising awareness of the disease, incremental healthcare spending across the world and the expected launch of emerging therapies during the forecast period.
Key players such as Bayer, Diffusion Pharmaceuticals, VBL Therapeutics, AstraZeneca, DNAtrix, Kintara Therapeutics, Oncoceutics, KaryoPharma, VBI Vaccines, Kazia Therapeutics, Aivita Biomedical, Medicenna Therapeutics, Immunomic Therapeutics, Inovio Pharmaceuticals, Orbus Therapeutics, Novartis, Ziopharm and others are involved in developing treatments for Brain Cancer.
The potential candidates with promising results in late- or phase III stage of clinical development include Ofranergene obadenovec (VB-111; VBL Therapeutics), Trans Sodium Crocetinate (Diffusion Pharmaceuticals), Eflornithine (Orbus Therapeutics) and Regorafenib (Bayer). Out of these, Orbus therapeutics’ Eflornithine is the only therapy being investigated solely for recurrent anaplastic astrocytoma (AA) while a majority of therapies in the pipeline are being investigated for GBM.
Followed by the late-stage products, a wide array of mid-stage or phase II promising interventions are expected to be launched in the near future in the market which include Durvalumab (MEDI4736; MedImmune), Tasadenoturev (DNX-2401; DNAtrix), ONC201 (Oncoceutics), Selinexor (KPT-330; Karyopharm Therapeutics), VBI-1901 (VBI Vaccines), Paxalisib (GDC-0084; Kazia Therapeutics), AV-GBM-1 (Aivita Biomedical), MDNA55 (Medicenna Therapeutics), VAL-083 (Dianhydrogalactitol; DelMar Pharmaceuticals), ITI-1000 (pp65 DC Vaccine; Immunomic Therapeutics), Everolimus (Novartis), Ad-RTS-hIL-12 in combination with Veledimex (Ziopharm) and INO-5401 + INO-9012 + Cemiplimab (REGN2810; Inovio Pharmaceuticals).
Request sample pages for more information on Brain Cancer Market Report @ www.delveinsight.com/sample-request/brain-cancer-market
Purpose: The Institute for Cancer Epidemiology in Lübeck is the first German Cancer Registry to implement InstantAtas. This reports incidence and mortality rates for major cancer sites over a five-year period for Schleswig-Holstein.
DNA Genotyping and Sequencing. A technician works among a fleet of desktop genomic sequencing machines at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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@Pathology2018 #Pathology #cancer #epidemiology #reproductivepathology #diagnosticspathology #digipath #cytopathology #histopathology #liverpath #SLPeeps #eyepath #medicine #hospital #health #plant #autopsy #experimentalpathology #renalpath #neuropath
DNA Genotyping and Sequencing. Technician prepares for a viral whole-genome sequencing experiment at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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DNA Genotyping and Sequencing. Vials containing DNA samples from studies of the genetic risk for cancer at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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Welcome to the 17th
International Conference on Pathology & Cancer Epidemiology
Conference Image
Today I stretch out my virtual hand
To you far away by land and sea
And hope that in 2018
I can personally greet them.
Progress in Pathology will be the noble task,
And in all its specialties we will debate;
Therefore for your participation we ask,
Which will be worth the wait.
Experience Scotlands special soul, its beauty in lochs and glens; and in merry company as a social goal find new ideas and friends. So mark the date in one year’s time, And prepare your scientific work; To join us on October 8 In beautiful Edinburgh.
Prof. Dr. Jochen Fries
Head of Translational Pathology
University Hospital of Cologne
Germany
DNA Genotyping and Sequencing. A bioinformatician analyzes DNA integration data from human papillomavirus (HPV) at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG). Storing, analyzing, integrating, and visualizing large amounts of biological data and related information, as well as providing access to it, is the focus of bioinformatics.
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DNA Genotyping and Sequencing.
A technician loads DNA samples into a desktop genomic sequencing machine at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG). Creator:Daniel Sone
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DNA Genotyping and Sequencing. A technician plates DNA samples for high-throughput genotyping and sequencing at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG). Also shown is an automated liquid-handling robot.
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DNA Genotyping and Sequencing. A technician at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG), washes arrays used in genome-wide association studies (GWAS). These studies search the genome for small variations, called single nucleotide polymorphisms or SNPs, that occur more frequently in people with a particular disease than in people without the disease.
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DNA Genotyping and Sequencing. A technician reviews data from high-throughput DNA genotyping and sequencing at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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Registration | Pathology 2018 | CME Pathology Conferences | CME Medical Conferences | USA Visit: pathology.euroscicon.com/
DNA Genotyping and Sequencing. A technician validates genetic variants identified through whole-exome sequencing at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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Purpose: The Institute for Cancer Epidemiology, the Cancer Registry in Lübeck, has implemented InstantAtas. They reports incidence and mortality rates for major cancer site over a five-year period for Schleswig-Holstein.
Meet experts from the arena of Pathology & Cancer Epidemiology at Pathology-2018.
#keynote_sessions #oral_presentation #poster #video #YRF #e-poster #workshop #exhibitors #sponsors
Hurry Up….Confirm your slots!!
@Pathology2018 #Callforabstracts !!#PathologyEurope #Pathologists #Cancer #Doctors #Researchers #nurse#Pathology #Cancer_Epidemiology#BreastPath #Cytopath #dermpath #GIPath #SurgPath #autopsy #plant #digitalpath #pathresidents
21 #CME credits
DNA Genotyping and Sequencing. Technician prepares for a viral whole-genome sequencing experiment at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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The main reason about Pathology & Cancer Epidemiology meeting is to discuss about various new upcoming technologies, future and current developments and lines of research determining the future of Pathology & Cancer Epidemiology. Experts from all over world will discuss the pros and cons of all the developments and how the upcoming technologies or procedures will change the face of Pathology, Pathologists, Pathology & Cancer Epidemiology Lecturers.
Platform to Showcase your product or services at CME accredited Pathology-2018
DNA Genotyping and Sequencing. Technician loads robot for genetic studies of the human papillomavirus (HPV) at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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DNA Genotyping and Sequencing.
Technician prepares source samples of DNA for quality-control checks during high-throughput genotyping and sequencing at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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DNA Genotyping and Sequencing. Centrifugation of DNA samples prior to high-throughput genotyping and sequencing at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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DNA Genotyping and Sequencing. A selection of DNA samples for amplification at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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DNA Genotyping and Sequencing. Automated DNA chip loading at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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DNA Genotyping and Sequencing. A bioinformatician analyzes DNA integration data from human papillomavirus (HPV) at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG). Storing, analyzing, integrating, and visualizing large amounts of biological data and related information, as well as providing access to it, is the focus of bioinformatics.
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DNA Genotyping and Sequencing. Technician prepares source samples of DNA for quality-control checks during high-throughput genotyping and sequencing at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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DNA Genotyping and Sequencing
A box containing used sequencing chips at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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DNA Genotyping and Sequencing. A technician observing cells under a microscope at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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The statement “everything causes cancer” has become a popular hyperbole, and one that some people use as rhetorical fodder to excuse their own dietary and lifestyle failures, particularly as they pertain to cancer risk. But the truth of the matter is that many common food items have,...
DNA Genotyping and Sequencing. Vials containing DNA samples from studies of the genetic risk for cancer at the Cancer Genomics Research Laboratory, part of the National Cancer Institute's Division of Cancer Epidemiology and Genetics (DCEG).
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@Pathology2018 #pathology #cancer #epidemiology #pathologists #pathologist #surgicalpath #histopath #cytopath #liverpath #plantpath #cancercytopath #breastpath #reproductivepath #hematopath #neuropath #nephropath #immunopath #anatomic #digitalpath #CME #plant #surgery #anatomy #medicine #doctor #nurses #hopitals