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If you are among the enormous crowd who have already pre-registered and wait patiently for the game but want to play a comparable game to keep yourself busy before the game starts, it’s the correct spot for you
Read more: www.bioinformaticsindia.com/gaming/top-5-battlegrounds-mo...
While dan was talking bioinformatics, I got to be a tourist. I was waiting for the guided tour of nearby petroglyphs.
Center for Research Informatics Bioinformatics Workshop at the University of Chicago, December 2015
Learn more about our workshop series at learn.cri.uchicago.edu
Photo ©2015 Brent Knepper
Photo from the 2024 College of Arts and Science (University of Saskatchewan) Convocation Awards Ceremony
In-silico functional annotation of a hypothetical protein from Edwardsiella tarda revealed Proline metabolism and apoptosis in fish
Authors: Sk Injamamul Islam, Saloa Sanjida, Moslema Jahan Mou, Sarower Mahfuj, Saad Nasir
Abstract: Edwardsiella tarda is one of the most widespread pathogens in aquatic species. A wide variety of diseases can be caused by this microbe, including Edwardsiella septicaemia but clinical signs of infection differ between species of fish. The fact that the bacteria is resistant to a wide range of antimicrobials is extremely important. Furthermore, several proteins in its genome are classified as hypothetical proteins (HPs). As a result, the current work sought to elucidate the roles of an HP found in the genome of E.tarda. To determine the structure and function of this protein, many bioinformatics methods were used. To locate the homologous protein, the sequence similarity was searched across the available bioinformatics databases. Quality evaluation methods were used to predict and confirm the secondary and tertiary structure. Additionally, the active site and interacting proteins were examined using CASTp and the STRING server. An important biological activity of the HP is that it contains single functional domains that may be responsible for host-cell invasion and autolysis. Further, protein-protein interactions within selected HP revealed several functional partners that are essential for bacterial survival. One such partner is the proline dehydrogenase/delta-1-pyrroline-5-carboxylate dehydrogenase (putA) of E. tarda. In addition, molecular docking and simulation results showed stable bonding between HP and Proline metabolism protein. Finally, the current work shows that the annotated HP is associated with possible mitochondrial metabolism and autolysis formation activities, as well as having a stable binding with the putA protein, which might be of significant relevance to future bacterial genetics research.
Keywords: Hypothetical protein, molecular docking, putA protein,
autolysis, E. tarda
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Howest Proclamatie Brugge - Bachelor Biomedische Laboratoriumtechnologie en Advanced Bachelor of Bioinformatics
Center for Research Informatics Bioinformatics Workshop at the University of Chicago, December 2015
Learn more about our workshop series at learn.cri.uchicago.edu
Photo ©2015 Brent Knepper