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Biologically Inspired Engineering: From Human Organs-on-Chips to Programmable Nanotherapeutics
Dr. Donald Ingber
Professor of Bioengineering, Harvard John. A. Paulson School of Engineering & Applied Sciences
Abstract
The Wyss Institute for Biologically Inspired Engineering at Harvard University that I lead has pioneered a new model for innovation, trans-disciplinary collaboration and technology translation. I will highlight engineering of “Organs-on-Chips” that recapitulate organ-level structure and functions as a way to replace animal testing for drug development, mechanistic discovery, and personalized medicine; nanotherapeutics that target to vascular occlusion sites like artificial platelets; anticoagulant surface coatings for medicine devices inspired by a plant; a ‘biospleen’ device that cleanses blood of pathogens and toxins in septic patients; and self-assembling DNA-based nanorobots that can be programmed to travel to cancer sites and kill tumor cells. This new bioinspired technology wave represents a major paradigm shift in medicine, and the novel organizational structure of the Institute offers an entirely new way to translate discoveries into breakthrough products in the academic setting.
Live Broadcast: coe.miami.edu/speaker/ingber
Dr. Donald Ingber is the Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University the Judah Folkman Professor of Vascular Biology at Harvard Medical School & Boston Children’s Hospital, and Professor of Bioengineering, Harvard John. A. Paulson School of Engineering & Applied Sciences. He is a member of the National Academy of Medicine, National Academy of Inventors, American Institute for Medical and Biological Engineering, and American Academy of Arts and Sciences.
Yu Mike Chi won best bioengineering poster, "A Custom Integrated High Input Impedance Biopotential Amplifier for Non-Contact and Mobile Health (ECG/EEG) Monitoring."
Biologically Inspired Engineering: From Human Organs-on-Chips to Programmable Nanotherapeutics
Dr. Donald Ingber
Professor of Bioengineering, Harvard John. A. Paulson School of Engineering & Applied Sciences
Abstract
The Wyss Institute for Biologically Inspired Engineering at Harvard University that I lead has pioneered a new model for innovation, trans-disciplinary collaboration and technology translation. I will highlight engineering of “Organs-on-Chips” that recapitulate organ-level structure and functions as a way to replace animal testing for drug development, mechanistic discovery, and personalized medicine; nanotherapeutics that target to vascular occlusion sites like artificial platelets; anticoagulant surface coatings for medicine devices inspired by a plant; a ‘biospleen’ device that cleanses blood of pathogens and toxins in septic patients; and self-assembling DNA-based nanorobots that can be programmed to travel to cancer sites and kill tumor cells. This new bioinspired technology wave represents a major paradigm shift in medicine, and the novel organizational structure of the Institute offers an entirely new way to translate discoveries into breakthrough products in the academic setting.
Live Broadcast: coe.miami.edu/speaker/ingber
Dr. Donald Ingber is the Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University the Judah Folkman Professor of Vascular Biology at Harvard Medical School & Boston Children’s Hospital, and Professor of Bioengineering, Harvard John. A. Paulson School of Engineering & Applied Sciences. He is a member of the National Academy of Medicine, National Academy of Inventors, American Institute for Medical and Biological Engineering, and American Academy of Arts and Sciences.
Drawing by Michael Liebschner
Originally published in:
Liebschner M., Wettergreen M.: "Optimization of Bone Scaffold Engineering for Load Bearing Applications." In Ferretti P., Ashammakhi N.: Topics in Tissue Engineering, e-book on tissue engineering, T. Waris & N. Ashammakhi, Chapter 22, www.tissue-engineering-oc.com, 2003.
Biologically Inspired Engineering: From Human Organs-on-Chips to Programmable Nanotherapeutics
Dr. Donald Ingber
Professor of Bioengineering, Harvard John. A. Paulson School of Engineering & Applied Sciences
Abstract
The Wyss Institute for Biologically Inspired Engineering at Harvard University that I lead has pioneered a new model for innovation, trans-disciplinary collaboration and technology translation. I will highlight engineering of “Organs-on-Chips” that recapitulate organ-level structure and functions as a way to replace animal testing for drug development, mechanistic discovery, and personalized medicine; nanotherapeutics that target to vascular occlusion sites like artificial platelets; anticoagulant surface coatings for medicine devices inspired by a plant; a ‘biospleen’ device that cleanses blood of pathogens and toxins in septic patients; and self-assembling DNA-based nanorobots that can be programmed to travel to cancer sites and kill tumor cells. This new bioinspired technology wave represents a major paradigm shift in medicine, and the novel organizational structure of the Institute offers an entirely new way to translate discoveries into breakthrough products in the academic setting.
Live Broadcast: coe.miami.edu/speaker/ingber
Dr. Donald Ingber is the Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University the Judah Folkman Professor of Vascular Biology at Harvard Medical School & Boston Children’s Hospital, and Professor of Bioengineering, Harvard John. A. Paulson School of Engineering & Applied Sciences. He is a member of the National Academy of Medicine, National Academy of Inventors, American Institute for Medical and Biological Engineering, and American Academy of Arts and Sciences.
Artist and mathematician Robert B. LISEK presents his recent bioengineering software projects SPECTRUM and CAPITAL, exploring the relationship between bio-molecular technology, code and issues arising from network technologies by combining his DNA code with codes of viruses and recently by testing influence of radioactive materials on biological entities.
Leaders in Software and Art was founded in 2009 to bring together the community of software and electronic artists, creative coders, data visualists, curators, collectors, digital and interactive agencies, and others who make their careers at the intersection of art and technology. [Photo © 2013 Emilio Vavarella]
Wireless sensors that monitor your heart even though they do not actually touch your skin are at the center of UC San Diego electrical engineering PhD student Yu Mike Chi’s dissertation. This technology – and the plan for commercializing it – earned Chi and his Cognionics team the top spot in the UC San Diego Entrepreneurship Challenge. The prize includes $25K in cash for the startup and $15K in legal services. Chi is developing these technologies under the guidance of professor Gert Cauwenberghs from the Department of Bioengineering at the UC San Diego Jacobs School of Engineering.
More information: www.jacobsschool.ucsd.edu/news/news_releases/release.sfe?...
Biologically Inspired Engineering: From Human Organs-on-Chips to Programmable Nanotherapeutics
Dr. Donald Ingber
Professor of Bioengineering, Harvard John. A. Paulson School of Engineering & Applied Sciences
Abstract
The Wyss Institute for Biologically Inspired Engineering at Harvard University that I lead has pioneered a new model for innovation, trans-disciplinary collaboration and technology translation. I will highlight engineering of “Organs-on-Chips” that recapitulate organ-level structure and functions as a way to replace animal testing for drug development, mechanistic discovery, and personalized medicine; nanotherapeutics that target to vascular occlusion sites like artificial platelets; anticoagulant surface coatings for medicine devices inspired by a plant; a ‘biospleen’ device that cleanses blood of pathogens and toxins in septic patients; and self-assembling DNA-based nanorobots that can be programmed to travel to cancer sites and kill tumor cells. This new bioinspired technology wave represents a major paradigm shift in medicine, and the novel organizational structure of the Institute offers an entirely new way to translate discoveries into breakthrough products in the academic setting.
Live Broadcast: coe.miami.edu/speaker/ingber
Dr. Donald Ingber is the Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University the Judah Folkman Professor of Vascular Biology at Harvard Medical School & Boston Children’s Hospital, and Professor of Bioengineering, Harvard John. A. Paulson School of Engineering & Applied Sciences. He is a member of the National Academy of Medicine, National Academy of Inventors, American Institute for Medical and Biological Engineering, and American Academy of Arts and Sciences.
Artist and mathematician Robert B. LISEK presents his recent bioengineering software projects SPECTRUM and CAPITAL, exploring the relationship between bio-molecular technology, code and issues arising from network technologies by combining his DNA code with codes of viruses and recently by testing influence of radioactive materials on biological entities.
Leaders in Software and Art was founded in 2009 to bring together the community of software and electronic artists, creative coders, data visualists, curators, collectors, digital and interactive agencies, and others who make their careers at the intersection of art and technology. [Photo © 2013 Emilio Vavarella]
Clusters of human endothelial cells captured using IBN’s custom-designed microdevice. Credit: Institute of Bioengineering and Nanotechnology
Professor Rui L. Reis was chosen as the 2017 recipient of the IET Harvey Engineering Research Prize for his outstanding contributions to research in the field of Medical Engineering, specifically for contributions to bioengineering, biomedical engineering, tissue engineering and biomaterials.
He presented a prize lecture on 20 March 2018, discussing his research and how the prize funding will be used to further it.
Photos courtesy of Trampenau photography - Steve Pearcy.
Artist and mathematician Robert B. LISEK presents his recent bioengineering software projects SPECTRUM and CAPITAL, exploring the relationship between bio-molecular technology, code and issues arising from network technologies by combining his DNA code with codes of viruses and recently by testing influence of radioactive materials on biological entities.
Leaders in Software and Art was founded in 2009 to bring together the community of software and electronic artists, creative coders, data visualists, curators, collectors, digital and interactive agencies, and others who make their careers at the intersection of art and technology. [Photo © 2013 Emilio Vavarella]
Pat Condon, head of UofL's National and International Scholarship Opportunities office, introduces Fulbright recipient Carrie Benzinger. Benzinger also received a Whitaker International Fellows Award for bioengineering.
Bioengineering stabilization measures applied on the cut slope, along a section of Nhau Pass. The road serves a predominantly agricultural, livestock rearing and timber-exploiting community.
Photo by ICEM
09/09/2015 - Daniel Fletcher, Chatterjee Professor of Bioengineering, University of California, Berkeley, USA at The Future of Precision Diagnostics with UC Berkeley at the World Economic Forum - Annual Meeting of the New Champions in Dalian, People's Republic of China 2015. Copyright by World Economic Forum / Ciaran McCrickard
Specially mixed salmon spawning gravel has been placed in the streambed, and straw mulch spread on the banks
Wireless sensors that monitor your heart even though they do not actually touch your skin are at the center of UC San Diego electrical engineering PhD student Yu Mike Chi’s dissertation. This technology – and the plan for commercializing it – earned Chi and his Cognionics team the top spot in the UC San Diego Entrepreneurship Challenge. The prize includes $25K in cash for the startup and $15K in legal services. Chi is developing these technologies under the guidance of professor Gert Cauwenberghs from the Department of Bioengineering at the UC San Diego Jacobs School of Engineering.
More information: www.jacobsschool.ucsd.edu/news/news_releases/release.sfe?...
09/09/2015 - Daniel Fletcher, Chatterjee Professor of Bioengineering, University of California, Berkeley, USA at The Future of Precision Diagnostics with UC Berkeley at the World Economic Forum - Annual Meeting of the New Champions in Dalian, People's Republic of China 2015. Copyright by World Economic Forum / Ciaran McCrickard
Wireless sensors that monitor your heart even though they do not actually touch your skin are at the center of UC San Diego electrical engineering PhD student Yu Mike Chi’s dissertation. This technology – and the plan for commercializing it – earned Chi and his Cognionics team the top spot in the UC San Diego Entrepreneurship Challenge. The prize includes $25K in cash for the startup and $15K in legal services. Chi is developing these technologies under the guidance of professor Gert Cauwenberghs from the Department of Bioengineering at the UC San Diego Jacobs School of Engineering.
More information: www.jacobsschool.ucsd.edu/news/news_releases/release.sfe?...
09/09/2015 - Amy Herr, Professor, Bioengineering, University of California, Berkeley, USA at The Future of Precision Diagnostics with UC Berkeley at the World Economic Forum - Annual Meeting of the New Champions in Dalian, People's Republic of China 2015. Copyright by World Economic Forum / Ciaran McCrickard
PROMES Camp students design micro devices to test pH levels during a microfluidics bioengineering lab experiment on July 9, 2019.
photo attribution: sean dreilinger durak.org
Todd P. Coleman
Neural Interaction Lab
Todd P. Coleman is an Associate Professor in the Department of Bioengineering at UCSD. His graduate training at MIT was in electrical engineering, while his postdoctoral training at MIT was in neuroscience. Dr. Coleman directs the Neural Interaction Laboratory at UCSD, where his research group builds flexible ?tattoo electronics? for neurological monitoring and brain-computer interfaces applications. Dr. Coleman is a science advisor for the Science & Entertainment Exchange (National Academy of Sciences). His research has been featured in CNN, the New York Times, and Popular Science.
view Todd Coleman - Where Will the Chips of Tomorrow Take Us? - TEDxS on a black background.
New Stanley Hall wins numerous awards for interdisciplinary research designs. This building houses bioengineering classes and lectures.
photo attribution: sean dreilinger durak.org
Todd P. Coleman
Neural Interaction Lab
Todd P. Coleman is an Associate Professor in the Department of Bioengineering at UCSD. His graduate training at MIT was in electrical engineering, while his postdoctoral training at MIT was in neuroscience. Dr. Coleman directs the Neural Interaction Laboratory at UCSD, where his research group builds flexible ?tattoo electronics? for neurological monitoring and brain-computer interfaces applications. Dr. Coleman is a science advisor for the Science & Entertainment Exchange (National Academy of Sciences). His research has been featured in CNN, the New York Times, and Popular Science.
view Todd Coleman - Where Will the Chips of Tomorrow Take Us? - TEDxS on a black background.
09/09/2015 - Daniel Fletcher, Chatterjee Professor of Bioengineering, University of California, Berkeley, USA at The Future of Precision Diagnostics with UC Berkeley at the World Economic Forum - Annual Meeting of the New Champions in Dalian, People's Republic of China 2015. Copyright by World Economic Forum / Ciaran McCrickard
PROMES Camp students design micro devices to test pH levels during a microfluidics bioengineering lab experiment on July 9, 2019.
Ronald E. Meyers delves into quantum physics research at the U. S. Army Research Laboratory. Meyers, fellow researcher Keith Deacon and Gert Cauwenberghs, a professor of bioengineering and biology at the University of California at San Diego earned a patent for a futuristic neural computer chip. Photo Credit: Photo illustration by David McNally, RDECOM
09/09/2015 - Amy Herr, Professor, Bioengineering, University of California, Berkeley, USA at The Future of Precision Diagnostics with UC Berkeley at the World Economic Forum - Annual Meeting of the New Champions in Dalian, People's Republic of China 2015. Copyright by World Economic Forum / Ciaran McCrickard
Students in Bioengineering Lab. Micro Pump Close ups of Microscope, Printer, etc., Santa Clara University
FMP DB# 3383
Mohammad Abidian, assistant professor of biomedical engineering, materials science and chemistry on April 3, 2014. (Photo credit: Curtis Chan)
PROMES Camp students design micro devices to test pH levels during a microfluidics bioengineering lab experiment on July 9, 2019.
Dept. of Chemical Engineering & Applied Chemistry - McGuigan Lab, Faculty of Applied Science & Engineering, University of Toronto
Photo by Sara Collaton
Wireless sensors that monitor your heart even though they do not actually touch your skin are at the center of UC San Diego electrical engineering PhD student Yu Mike Chi’s dissertation. This technology – and the plan for commercializing it – earned Chi and his Cognionics team the top spot in the UC San Diego Entrepreneurship Challenge. The prize includes $25K in cash for the startup and $15K in legal services. Chi is developing these technologies under the guidance of professor Gert Cauwenberghs from the Department of Bioengineering at the UC San Diego Jacobs School of Engineering.
More information: www.jacobsschool.ucsd.edu/news/news_releases/release.sfe?...
Wireless sensors that monitor your heart even though they do not actually touch your skin are at the center of UC San Diego electrical engineering PhD student Yu Mike Chi’s dissertation. This technology – and the plan for commercializing it – earned Chi and his Cognionics team the top spot in the UC San Diego Entrepreneurship Challenge. The prize includes $25K in cash for the startup and $15K in legal services. Chi is developing these technologies under the guidance of professor Gert Cauwenberghs from the Department of Bioengineering at the UC San Diego Jacobs School of Engineering.
More information: www.jacobsschool.ucsd.edu/news/news_releases/release.sfe?...
15 February 2016, Rome, Italy - Chittaranjan Kole, Jacob School of Biotechnology & Bioengineering, Allahabad, India, Facing the challenges of climate change: Adaptation of the crop and forestry sectors - FAO International Symposium on “The Role of Agricultural Biotechnologies in Sustainable Food Systems and Nutrition", FAO headquarters (Sheikh Zayed Centre).
Photo credit must be given: ©FAO/Giuseppe Carotenuto. Editorial use only. Copyright ©FAO.
Researchers at the Wayne State University Bioengineering Center examine a crash test dummy, circa 1960s. More information: engineering.wayne.edu/bme/
Artist and mathematician Robert B. LISEK presents his recent bioengineering software projects SPECTRUM and CAPITAL, exploring the relationship between bio-molecular technology, code and issues arising from network technologies by combining his DNA code with codes of viruses and recently by testing influence of radioactive materials on biological entities.
Leaders in Software and Art was founded in 2009 to bring together the community of software and electronic artists, creative coders, data visualists, curators, collectors, digital and interactive agencies, and others who make their careers at the intersection of art and technology. [Photo © 2013 Emilio Vavarella]