Jellyfish
Antihypertensive Effect of Long-Term Oral Administration of Jellyfish (Rhopilema esculentum) Collagen Peptides on Renovascular Hypertension
Yongliang Zhuang,* Liping Sun, Yufeng Zhang, and Gaoxiang Liu
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Abstract
Antihypertensive effect of long-term oral administration of jellyfish (Rhopilema esculentum) collagen peptides (JCP) on renovascular hypertension rats (RVHs) was evaluated. The systolic blood pressure and diastolic blood pressure of the RVHs were significantly reduced with administration of JCP (p 0.05). Furthermore, effect of JCP on angiotensin II (Ang II) concentration of plasma had no significance (p > 0.05), but JCP significantly inhibited the Ang II concentration in RVHs’ kidney (p 0.05). Interestingly, the SBP and DBP of JCP-C group showed no significant changes during long-term oral treatment with high dose JCP (p > 0.05). These results indicated that JCP had good long-term antihypertensive effects on RVHs, but had no effects for the blood pressures of normal rats.
As shown in Figure 2, the heart rates of the MC group were significant higher than the captopril group and NC group (p 0.05), and the heart rats of JCP-2 group had no significance with captopril group and NC group (p > 0.05).
Jellyfish
Antihypertensive Effect of Long-Term Oral Administration of Jellyfish (Rhopilema esculentum) Collagen Peptides on Renovascular Hypertension
Yongliang Zhuang,* Liping Sun, Yufeng Zhang, and Gaoxiang Liu
Author information ► Article notes ► Copyright and License information ► Disclaimer
This article has been cited by other articles in PMC.
Go to:
Abstract
Antihypertensive effect of long-term oral administration of jellyfish (Rhopilema esculentum) collagen peptides (JCP) on renovascular hypertension rats (RVHs) was evaluated. The systolic blood pressure and diastolic blood pressure of the RVHs were significantly reduced with administration of JCP (p 0.05). Furthermore, effect of JCP on angiotensin II (Ang II) concentration of plasma had no significance (p > 0.05), but JCP significantly inhibited the Ang II concentration in RVHs’ kidney (p 0.05). Interestingly, the SBP and DBP of JCP-C group showed no significant changes during long-term oral treatment with high dose JCP (p > 0.05). These results indicated that JCP had good long-term antihypertensive effects on RVHs, but had no effects for the blood pressures of normal rats.
As shown in Figure 2, the heart rates of the MC group were significant higher than the captopril group and NC group (p 0.05), and the heart rats of JCP-2 group had no significance with captopril group and NC group (p > 0.05).