TheJCB
Vol. 191, Issue 5 - toc1
Hartman et al. reveal that Drosophila Boi sequesters Hedgehog on the surface of ovarian apical cells to limit follicle stem cell proliferation. When wild-type Boi is replaced by a mutant version (green) that can’t bind Hedgehog (red), the signaling molecule accumulates around follicle stem cells, causing them to overproliferate.
This image is available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.
Reference: Hartman et al. (2010) J. Cell Biol.191, 943-952.
Published on: November 29, 2010.
doi: 10.1083/jcb.201007142
Read the full article online at:
Vol. 191, Issue 5 - toc1
Hartman et al. reveal that Drosophila Boi sequesters Hedgehog on the surface of ovarian apical cells to limit follicle stem cell proliferation. When wild-type Boi is replaced by a mutant version (green) that can’t bind Hedgehog (red), the signaling molecule accumulates around follicle stem cells, causing them to overproliferate.
This image is available to the public to copy, distribute, or display under a Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported license.
Reference: Hartman et al. (2010) J. Cell Biol.191, 943-952.
Published on: November 29, 2010.
doi: 10.1083/jcb.201007142
Read the full article online at: