Vol. 204, Issue 1: etoc 1

b-Galactosidase activity (blue) indicates senescent cells in the liver of hyperthyroid mice. Zambrano et al. describe how thyroid hormone and its receptor cause increased mitochondrial respiration and reactive oxygen species production, leading to DNA damage and premature cell senescence.

 

Image courtesy of Zambrano et al.

 

Reference: Zambrano et al. (2014) J. Cell Biol. 204:129-146

Published on January 6, 2014.

doi: 10.1083/jcb.201305084

 

Read the full article online at: jcb.rupress.org/content/204/1/129.full

 

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