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An apoptotic cell (green) is extruded from the zebrafish larval epidermis by an actin (red) and myosin ring that forms in the adjacent live cells. Gu et al. reveal that dying cells tell their neighbors to squeeze them out of the tissue by producing the sphingolipid sphingosine-1-phosphate.

Image by Tetyana Forostyan, © 2011 Gu et al.

Reference: Gu et al. (2011) J. Cell Biol. 193, 667-676.

Published on: May 16, 2011.

doi: 10.1083/jcb.201010075

Read the full article online at: jcb.rupress.org/content/193/4/667.full

Figure 8 from FTY720 Story. Its Discovery and the Following Accelerated Development of Sphingosine 1-Phosphate Receptor Agonists as Immunomodulators Based on Reverse Pharmacology Published in Perspectives in Medicinal Chemistry

Caleb Studstill explains his poster titled "Understanding the Role of Sphingosine Kinase 2 in Immune Modulation and Viral Persistenc" Thursday, April 13 during the Research Poster Session @ Missouri Life Sciences Week 2017 | Photo by Roger Meissen, Bond LSC

Figure 6 from FTY720 Story. Its Discovery and the Following Accelerated Development of Sphingosine 1-Phosphate Receptor Agonists as Immunomodulators Based on Reverse Pharmacology Published in Perspectives in Medicinal Chemistry

Figure 7 from FTY720 Story. Its Discovery and the Following Accelerated Development of Sphingosine 1-Phosphate Receptor Agonists as Immunomodulators Based on Reverse Pharmacology Published in Perspectives in Medicinal Chemistry

Electron micrograph of wild-type Drosophila photoreceptors. Yonamine et al. demonstrate that overexpressing sphingosine kinase 2 causes photoreceptor degeneration and boosts the lysosomal degradation of light-sensing proteins such as Rhodopsin by increasing the levels of dihydrosphingosine 1 phosphate compared to sphingosine 1 phosphate.

Image courtesy of Kunio Nagashima,Jairaj Acharya, and Usha Acharya.

Reference:Yonamine et al. (2011) J. Cell Biol.192, 557-567 .

Published on: February 21, 2011.

doi: 10.1083/jcb.201004098

Read the full article online at: jcb.rupress.org/content/192/4/557.full

How We Match Lipids in Images. a) We look at a standard sample of a specific type of lipid using a special kind of light called spontaneous Raman spectroscopy. Then, we process this data to create a reference pattern. b) We take a picture of a sample using another type of light called SRS to create a special image called a Hyperspectral Image (HSI). c) Each tiny dot in this image holds information about the type of lipids present there. We compare these dots to our reference pattern using a method called spectral angle mapping, which helps us see if they're similar. If they're different, they'll have a lower cosine similarity. d) We show an example of a mouse brain picture with highlighted areas where we've found specific lipids like sphingosine, cholesterol, and TAG (triacylglyceride). The intensity of each pixel in these areas reflects how similar they are to our reference pattern. SRS stands for Stimulated Raman Scattering, and HSI stands for Hyperspectral Image. (Panels (a) and (b) were made with BioRender.com)

Past Within Our Reach Investigator Gary Gilkeson, MD presents his poster “Role of Sphingosine Kinase I in Inflammatory Arthritis.”

Awad Mohamed - "Differential Sphingosine-1-Phosphate Receptor 1 Expression in the Heart and Brain Following Transient Middle Cerebral Artery Occlusion in Mouse Model"

Mentor: Rayna Gonzales, PhD

RT @Richard_Hoehn: Tracy Rice explaining pneumonia in burn patients #sphingosine @SphingolipidsUS @MJEtrnnflt @ucsurgpd #ASC2016 t.co/wP7lPUVhx7

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Chemistry

Which of the following molecules contain sphingosine? Select all that apply.

#ittutoria #chemistry #question

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