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Title: The Nose, paranasal sinuses, nasolacrimal passageways, and olfactory organ in man : a genetic, developmental, and anatomico-physiological consideration
Creator: Schaeffer, Jacob Parsons
Publisher: Philadelphia : Blakiston's Son & Co.
Sponsor: Open Knowledge Commons
Contributor: Columbia University Libraries
Date: 1920
Language: eng
Includes index
If you have questions concerning reproductions, please contact the Contributing Library.
Note: The colors, contrast and appearance of these illustrations are unlikely to be true to life. They are derived from scanned images that have been enhanced for machine interpretation and have been altered from their originals.
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8th Session of the Intergovernmental Technical Working Group on Animal Genetic Resources for Food and Agriculture
www-data.fao.org/ag/againfo/programmes/en/genetics/angrve...
©FAO/Grégoire Leroy
8th Session of the Intergovernmental Technical Working Group on Animal Genetic Resources for Food and Agriculture
www-data.fao.org/ag/againfo/programmes/en/genetics/angrve...
©FAO/Grégoire Leroy
Our newest investment: AI-driven epigenetic editing for novel modes of precision medicine.
Moonwalk’s molecular tools are like CRISPR for methylation tags, and not the DNA itself.
Genes are the firmware, epigenetics is the software. Moonwalk.Bio
Excerpts from today’s news
• From Genetic Engineering & Biotech News:
“The company has an impressive leadership team with deep expertise in areas such as epigenetic editing and clinical product development. In addition to Aravanis, Moonwalk’s co-founders include Arash Jamshidi, PhD, and Justin Valley, PhD, as well as scientific co-founder Feng Zhang, PhD, [pioneer of CRISPR editing]. Since leaving his role as Illumina’s chief technology officer last year, Aravanis has spent the bulk of his time working on building Moonwalk.
Moonwalk plans to develop a pipeline of treatments capable of using the cells’ natural regulation system to accurately and permanently control multiple genes in a single step without making changes to the primary DNA sequence. This is an important point and one that is highlighted by several companies that are trying to reprogram diseased cells by targeting the epigenetic code.
Activating or suppressing genes by methylating or demethylating particular targets rather than snipping and inserting DNA sidesteps some of the inherent risks of editing genes directly including potential structural changes or unintended insertions. An added benefit is the durability of epigenetic changes. The data suggests that modifications to methylation do stay in place and those changes are successfully transmitted to daughter cells even after multiple cell divisions.
‘There’s been a lot of evidence mounting over the years about the importance of the epigenome in health and disease. And also obviously cells change a lot as we age and as they develop pathologies. And that’s reflected in the epigenome,’ Aravanis said. ‘It’s a very appealing concept to be able to kind of see root level changes in the epigenome and then have a technology to modify it and then develop therapeutics based on that.’
Moonwalk claims to be the first company to couple an epigenetic discovery platform with precise engineering. Its proprietary technology has two key components. A so-called read component is designed to capture methylation information from the entire genome—about 28 million sites. It gives the company insights into the methylation present in both healthy and diseased states, allowing it to make predictions about complex methylation patterns as well as identify which are the best targets to hit.
The rubber meets the road in the second component of the company’s platform. This is where the company uses editing technology designed by Zhang, the company’s scientific co-founder, to modify methylation states in the genome. In addition to his work on CRISPR, Zhang is perhaps ‘one of the earliest inventors of this concept of modifying the epigenome directly,’ Aravanis noted, making him a natural fit for the company.”
• From Longevity Tech:
“’While changes to the genome are irreversible, edits to the epigenome can be reprogrammed in different ways,’ said Moonwalk CEO Aravanis, who co-authored a recent paper in Nature describing a DNA methylation atlas of human cells. ‘Epigenetic changes determine whether genes are turned on or off, and can potentially reverse disease, broadening the therapeutic landscape to find potential cures previously thought impossible.’
Potential in age-related disease: Cellular reprogramming is a hot topic in longevity, and Aravanis told us that Moonwalk is studying its effect on the epigenome.
‘By converting transcription factor expression protocols into more precise epigenetic programs, it may be possible to achieve the benefits of programming or partial reprogramming, but with more specific control over cell state,’ he said. ‘For example, to gain the benefits of higher function without losing the somatic features of cells.’
When it comes to the company’s potential in targeting diseases of aging specifically, Aravanis told us that epigenetic alterations are “a hallmark of aging that strongly correlate with decline in cell function.”
‘There is increasing evidence that these alterations are causally related to loss of function,’ he said. ‘Moonwalk’s epigenome engineering platform can identify these epigenetics changes with unprecedented resolution, predict which targets may be causally related to the loss of function, and then reverse their methylation state, testing them as candidates to restore cell function.’”
• From the WSJ :
“Proponents say this new twist on genetic medicine, ‘epigenetic editing,’ promises to lead to treatments or cures for a variety of common medical scourges, such as cancer and chronic hepatitis B.
Epigenetic therapy attempts to tap nature’s method of regulating what a gene does, or its expression. Cells in various organs harbor the same genes. But a system of controlling which genes are turned on or off—epigenetics—determines whether a cell turns into a heart, brain or other type of cell.
South San Francisco, Calif.-based Moonwalk, which was founded in 2022 and operated quietly until recently, seeks to harness a form of epigenetic control that involves adding chemical tags, known as methyl groups, to DNA. Adding a methylation tag suppresses a gene, while removing one can allow it to be activated.
Bing Ren, director of the Center for Epigenomics at the University of California, San Diego, said he is optimistic the approach could be a breakthrough, partly because it could open new angles of attack on diseases.”
The Oaks Theater presented a night of mutilation, murder, and music with a showing of Repo! The Genetic Opera -- complete with a "Rocky Horror" style floor show from Pittsburgh's burgeoning Repo! Shadow Cast: The Night Surgeons.
Fans signing a Repo The Genetic Opera Roadshow banner following a screening of the film at the Bloor Cinema in downtown Toronto on Nov 21, 2008.
Repo is currently making a limited theatrical run across the US and Canada and is selling out at almost every screening.
Security finally had to escort fans out because so many people wanted to sign the banner and the theatre had to be cleared for the next screening.
Repo is a Horror musical directed by famed SAW 2,3,4 Director Darren Lynn Bousman.
The film is an incredible event and must be seen with a crowd to get the full experience.
Many are calling REPO the next Rocky Horror and the fanbase is growing strong with sold out screenings throughout the US and Canada.
Fans are showing up in costume, singing along with the film and performing musical numbers in the streets to spread the word on a film Lionsgate originaly thought would have no audience.
I have never seen such a frenzy for a film in my life.
Please vist www.repo-opera.com for more info on the film.
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For information on using this photo please contact me through my e-mail listed in my profile.
Technoid is a military robot. They can shoot and hover. All of them is using Destabilization Swords that can destroy any Toa, Matoran etc. system and make 'em unable to reform at Red Star. This version of Technoid is enriched by The Sword of Power. Sword gained this specific Technoid large mechanical muscles and gifted it with consciousness.
8th Session of the Intergovernmental Technical Working Group on Animal Genetic Resources for Food and Agriculture
www-data.fao.org/ag/againfo/programmes/en/genetics/angrve...
©FAO/Grégoire Leroy
this montage is a genetic portrait mixing my face and my bro's face
im on the half-left (blue) of photo and my brother is the half-right (brown)
:)
It's crazy
This ATC was made for the DNA my ATC swap on swapbot. Collaged from images from an old textbook and the machine is one of jerseybarb85s in the collage images group.
Microworld Arcadia was a group art show organised by Genetic Moo at the Arcadecardiff gallery in the Queens Arcade shopping mall for two weeks in May 2013. The show consisted of interactive and generative artworks by different artists. The art works responded to the audience, the gallery and importantly to each other, so the space was constantly changing in pixels, sound, colour and motion. Each day different works were brought together in different combinations.
On the first day you can see The Virus & Comb Jellies by Genetic Moo, Chromatic Play sculptures by Tine Bech and Primordial sound and generative visuals by Jockel Liess.
Microworld Arcadia was a big success breaking attendance records for the gallery and we plan to take the show on tour in the future, working with different sets of local artists each time to create interactive digital Microworlds around the UK and beyond.
For more information about the show see www.geneticmoo.com
Some think that this might help fight the world hunger, despite the health and environmental risks. Others say that there is already enough food being produced within common methods of farming and that the real problem is poverty, meaning the poor and hungry cannot buy it, and inequality of countries or displacement of rations.
Taken a long time ago (1988) for the Queen's visit to Lichfield Cathedral to distribute the Maundy Money.
I had to wait for the arrival of digital to manipulate the picture as I wanted. I tried using traditional methods but it never got to looking any thing like I wanted. I think this does look very similar to how I wanted it to look in the first place. Taken with an Olympus OM2 on Ilford FP4 (original pic)
Prof Sir Alec Jeffreys, speaking to the students at the Golden Jubilee Lecture of Indian Institute of Technology (IIT) Delhi on 27 October 2010. Follow us on Twitter: www.twitter.com/ukinindia
8th Session of the Intergovernmental Technical Working Group on Animal Genetic Resources for Food and Agriculture
www-data.fao.org/ag/againfo/programmes/en/genetics/angrve...
©FAO/Grégoire Leroy
This is a little dwarf rat that popped up in one of my litters. The larger rat is his litter mate. You can see the striking size difference between the two!
Seed orchard. Dorena Genetic Resource Center, Cottage Grove, Oregon.
Photo by: Unknown
Date: 1968
Credit: USDA Forest Service, Region 6, State and Private Forestry, Forest Health Protection.
Source: Division of Timber Management, Insect and Disease Control Branch print collection; Regional Office, Portland, Oregon.
For more about the Dorena Genetic Resource Center, see: www.fs.usda.gov/detail/r6/landmanagement/resourcemanageme...
Image provided by USDA Forest Service, Pacific Northwest Region, State and Private Forestry, Forest Health Protection: www.fs.usda.gov/main/r6/forest-grasslandhealth
This workshop took place from 4-5 July 2016 in Rome, Italy – two days before the 9th Session of the Intergovernmental Technical Working Group on Animal Genetic Resources for Food and Agriculture
More information: www.fao.org/ag/againfo/programmes/en/genetics/natcord.html
This workshop took place from 4-5 July 2016 in Rome, Italy – two days before the 9th Session of the Intergovernmental Technical Working Group on Animal Genetic Resources for Food and Agriculture
More information: www.fao.org/ag/againfo/programmes/en/genetics/natcord.html
This is a little dwarf rat that popped up in one of my litters. The larger rat is his litter mate. You can see the striking size difference between the two!
Microworld Arcadia was a group art show organised by Genetic Moo at the Arcadecardiff gallery in the Queens Arcade shopping mall for two weeks in May 2013. The show consisted of interactive and generative artworks by different artists. The art works responded to the audience, the gallery and importantly to each other, so the space was constantly changing in pixels, sound, colour and motion. Each day different works were brought together in different combinations.
On the first day you can see us setting up The Virus and Comb jellies which face each other across the room, and also It's Alive! in the corner.
Microworld Arcadia was a big success breaking attendance records for the gallery and we plan to take the show on tour in the future, working with different sets of local artists each time to create interactive digital Microworlds around the UK and beyond.
For more information about the show see www.geneticmoo.com
One of the current dogs available for adoption from Keshet, is Ruxin. Ruxin is a Eurasier.
We find that Ruxin displays the playful/people friendly aspect of the Samoyed's average behaviour and the protective instincts of the Chow Chow. His colouring and purple tongue definitely showcase the Chow in his genetic makeup, but there is no mistaking he takes after the Keeshund in the proportions of his face and ears.
For more information on Ruxin go to: www.keshetkennels.com/rescue/for-adoption/ruxin/