Pipeline 2
A major challenge of the Human Genome Project was "annotation", or making descriptive sense, of the raw DNA sequence. Output from an automated capillary sequencer, with each of the four DNA bases labeled a different colour, forms the raw data. These data are then processed with various annotation "pipelines", including assembly of the raw reads into larger "contigs" and ultimately a finished genome sequence.
Represented here is the transition from primary sequence data (left) through the "brain filtering" and computer processing of bioinformatics (right). The image has been treated with a simulation of the "bleach bypass" developing technique used on photographic film in the pre-digital, genome project era.
[The preceding pompous description goes with this piece of "art", submitted for consideration as part of a gallery exhibit for an institutional fundraiser. I can call it pompous with impunity, because I wrote it.]
Licensed to the U.S. National Institute of Dental and Craniofacial Research (NIDCR) for use in this article:
www.nidcr.nih.gov/ScienceSpotlight/InterviewsbyTopic/Head...
Pipeline 2
A major challenge of the Human Genome Project was "annotation", or making descriptive sense, of the raw DNA sequence. Output from an automated capillary sequencer, with each of the four DNA bases labeled a different colour, forms the raw data. These data are then processed with various annotation "pipelines", including assembly of the raw reads into larger "contigs" and ultimately a finished genome sequence.
Represented here is the transition from primary sequence data (left) through the "brain filtering" and computer processing of bioinformatics (right). The image has been treated with a simulation of the "bleach bypass" developing technique used on photographic film in the pre-digital, genome project era.
[The preceding pompous description goes with this piece of "art", submitted for consideration as part of a gallery exhibit for an institutional fundraiser. I can call it pompous with impunity, because I wrote it.]
Licensed to the U.S. National Institute of Dental and Craniofacial Research (NIDCR) for use in this article:
www.nidcr.nih.gov/ScienceSpotlight/InterviewsbyTopic/Head...