Small cell lung carcinoma with extensive bronchial mucosal involvement; possible SCLC in situ Case 270
This is an autopsy case of small cell lung carcinoma (SCLC) with extensive tumor involvement of bronchial epipthelium, glands and glandular ducts. Much of the mucosal involvement is not immediately adjacent to areas of invasive SCLC. Although it has been suggested (and it is possible) that mucosal tumor involvement in this case represents invasion by underlying invasive tumor, I believe that that explanation is unlikely. A precursor of SCLC has not yet been identified. Its identification and acceptance would require studies carefully focusing on the examination of the bronchial mucosa in a large number of resection and/or autopsy specimens. At the present time present specimens of this type are not often encountered in any one institution.
This photo shows full thickness replacement of the bronchial surface epithelium by malignant cells. Chromogranin, synaptophysin and CD56 immunostains were all negative in the intraepithelial malignant cells. The tissue had been embeddded in paraffin for more than 10 years prior to the performance of the immunostains.
Small cell lung carcinoma with extensive bronchial mucosal involvement; possible SCLC in situ Case 270
This is an autopsy case of small cell lung carcinoma (SCLC) with extensive tumor involvement of bronchial epipthelium, glands and glandular ducts. Much of the mucosal involvement is not immediately adjacent to areas of invasive SCLC. Although it has been suggested (and it is possible) that mucosal tumor involvement in this case represents invasion by underlying invasive tumor, I believe that that explanation is unlikely. A precursor of SCLC has not yet been identified. Its identification and acceptance would require studies carefully focusing on the examination of the bronchial mucosa in a large number of resection and/or autopsy specimens. At the present time present specimens of this type are not often encountered in any one institution.
This photo shows full thickness replacement of the bronchial surface epithelium by malignant cells. Chromogranin, synaptophysin and CD56 immunostains were all negative in the intraepithelial malignant cells. The tissue had been embeddded in paraffin for more than 10 years prior to the performance of the immunostains.