Scleroderma - Case 291
The most frequent pulmonary lesions in scleroderma are pulmonary hypertensive arteriopathy and interstitial pneumonia most often resembling UIP. Either or both of these lesions may be present; in this case both are present. This image shows interstitial pneumonia with extensive inflammation, fibrosis and honeycomb changes. The pulmonary arterioles and arteries show marked medial muscle hyperplasia and intimal fibrosis with significant lumenal narrowing. A large fibroblastic focus is seen in the center of the upper half of the image..
Scleroderma - Case 291
The most frequent pulmonary lesions in scleroderma are pulmonary hypertensive arteriopathy and interstitial pneumonia most often resembling UIP. Either or both of these lesions may be present; in this case both are present. This image shows interstitial pneumonia with extensive inflammation, fibrosis and honeycomb changes. The pulmonary arterioles and arteries show marked medial muscle hyperplasia and intimal fibrosis with significant lumenal narrowing. A large fibroblastic focus is seen in the center of the upper half of the image..