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Mouse Model of Stuttering

In a mouse model of stuttering (lower panel), there are fewer astrocytes, shown in green, compared to controls (upper panel) in the corpus callosum, the area of the brain that enables the left and right hemispheres to communicate.

Researchers believe that stuttering — a potentially lifelong and debilitating speech disorder — stems from problems with the circuits in the brain that control speech, but precisely how and where these problems occur is unknown. Using a mouse model of stuttering, scientists report that a loss of cells in the brain called astrocytes are associated with stuttering. The mice had been engineered with a human gene mutation previously linked to stuttering. The study, which appeared online in the Proceedings of the National Academy of Sciences, offers insights into the neurological deficits associated with stuttering.

 

Read more:

www.nih.gov/news-events/news-releases/nih-study-mice-iden...

 

Credit: Tae-Un Han, Ph.D., National Institute on Deafness and Communication Disorders, NIH

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Uploaded on August 22, 2019