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Human Differentiated Myotubes

Researchers have determined that the protein complex TFIID controls stem cell genes that repair skeletal muscle. This image shows human differentiated skeletal muscle fibers (myotubes, in green) expressing the protein MyoD (stained in red), which cooperates with TFIID in causing muscle stem cells to become muscle tissue. Cell nuclei are stained in blue. This discovery may help develop strategies that activate stem cells to repair muscle degenerated by aging or diseases like muscular dystrophy and cancer.

 

This image is not owned by the NIH. It is shared with the public under license. If you have a question about using or reproducing this image, please contact the creator listed in the credits. All rights to the work remain with the original creator.

 

Credit: Alessandra Dall'Agnese, Sanford-Burnham Prebys Medical Discovery Institute

 

NIH funding from: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

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Uploaded on July 18, 2016