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Prkar2a Knockout Mice
Brain sections from a Prkar2a knockout mouse (left) and wild type mouse (right) after two weeks of free access to running wheels, followed by blocking of running activity.
Prkar2a knockout mice resist diet-induced obesity and run more than wild-type mice when given access to running wheels. As shown on the left, C-fos (red) appears to increase in brain regions associated with voluntary motor activity and reward (dentate gyrus, medial and lateral habenula). Credit: E. London and C. Stratakis, NICHD
Prkar2a Knockout Mice
Brain sections from a Prkar2a knockout mouse (left) and wild type mouse (right) after two weeks of free access to running wheels, followed by blocking of running activity.
Prkar2a knockout mice resist diet-induced obesity and run more than wild-type mice when given access to running wheels. As shown on the left, C-fos (red) appears to increase in brain regions associated with voluntary motor activity and reward (dentate gyrus, medial and lateral habenula). Credit: E. London and C. Stratakis, NICHD