Matchmakers
Note: We would love to know how you are re-using our graphics, especially if you are a teacher using them in the classroom. Send us an email: knowablemagazine AT annualreviews DOT org
Immunologists can figure out what antigen a T cell responds to by sequencing the genes that code for the T cell receptor. A T cell receptor is made up of two proteins, each encoded by a separate gene. In the past, gene sequencing could only be done using thousands or millions of cells at a time, so it was impossible to match a T cell’s two receptor genes back together. Using newly developed techniques, researchers can now sequence the genes from many individual T cells simultaneously and keep track of T cell receptor gene pairs. This has allowed them to match T cell receptors to their antigens.
Read more: "Humanizing immunology"
Matchmakers
Note: We would love to know how you are re-using our graphics, especially if you are a teacher using them in the classroom. Send us an email: knowablemagazine AT annualreviews DOT org
Immunologists can figure out what antigen a T cell responds to by sequencing the genes that code for the T cell receptor. A T cell receptor is made up of two proteins, each encoded by a separate gene. In the past, gene sequencing could only be done using thousands or millions of cells at a time, so it was impossible to match a T cell’s two receptor genes back together. Using newly developed techniques, researchers can now sequence the genes from many individual T cells simultaneously and keep track of T cell receptor gene pairs. This has allowed them to match T cell receptors to their antigens.
Read more: "Humanizing immunology"