Qiao's Pathology (Art and Science in Medicine)
Qiao's Pathology: Chemotherapy Effects on Breast Cancer Cells
Microscopic photo showing clusters of residual tumor cells after neoadjuvant chemotherapy. Overall, the tumor cellularity is markedly decreased. The borders of tumor clusters are well defined and tend to shrink away from the stroma. This feature should not be misinterpreted as lymphovascular invasion. Other changes include distortion of glandular architecture, enlarged tumor cells due to increased cytoplasm, cytoplasmic vacuolization and eosinophilic change, pleomorphic and bizarre nuclei, and decreased mitotic activity. H&E stain. 40x original objective magnification. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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Qiao's Pathology: Chemotherapy Effects on Breast Cancer Cells
Microscopic photo showing clusters of residual tumor cells after neoadjuvant chemotherapy. Overall, the tumor cellularity is markedly decreased. The borders of tumor clusters are well defined and tend to shrink away from the stroma. This feature should not be misinterpreted as lymphovascular invasion. Other changes include distortion of glandular architecture, enlarged tumor cells due to increased cytoplasm, cytoplasmic vacuolization and eosinophilic change, pleomorphic and bizarre nuclei, and decreased mitotic activity. H&E stain. 40x original objective magnification. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.
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