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Qiao's Pathology: Chemotherapy Effects on Breast Cancer Cells

Microscopic photo showing a cluster of residual tumor cells after neoadjuvant chemotherapy. Portion of the tumor glandular lining epithelium exhibits morphologic changes, include distortion of glandular architecture, enlarged tumor cells due to increased cytoplasm, cytoplasmic vacuolization and eosinophilic change, pleomorphic and bizarre nuclei, and decreased mitotic activity. Histiocytes are cleaning the falling tumor cells in the lumen. H&E stain. 40x original objective magnification. Jian-Hua Qiao, MD, FCAP, Los Angeles, CA, USA.

 

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Uploaded on September 15, 2016