Lanthanum carbonate - Duodenum
The following information was mostly obtained from Dr. Raul S. Gonzalez’s article “Lanthaum Carbonate Deposition” in Pathology Outlines (tinyurl.com/rm62qq9).
Lanthanum carbonate is an oral phosphate binder used to treat hyperphosphatemia in patients with end stage renal disease undergoing dialysis. This medication can be deposited throughout the GI tract mucosa, most commonly in the stomach. It appears as aggregates of brown, purple to red amorphous material; usually within histiocytes. It can be mistaken for iron. Occasional fragments may be Prussian Blue +. Involved mucosa may be intact or eroded. Deposition may be detected for many years after cessation of therapy and may be detected radiographically. The identity of this material can be confirmed by energy dispersive X-ray spectrometry.
Image contributed by Dr. Ziad El-Zaatari - @ziad_zaatsri
Lanthanum carbonate - Duodenum
The following information was mostly obtained from Dr. Raul S. Gonzalez’s article “Lanthaum Carbonate Deposition” in Pathology Outlines (tinyurl.com/rm62qq9).
Lanthanum carbonate is an oral phosphate binder used to treat hyperphosphatemia in patients with end stage renal disease undergoing dialysis. This medication can be deposited throughout the GI tract mucosa, most commonly in the stomach. It appears as aggregates of brown, purple to red amorphous material; usually within histiocytes. It can be mistaken for iron. Occasional fragments may be Prussian Blue +. Involved mucosa may be intact or eroded. Deposition may be detected for many years after cessation of therapy and may be detected radiographically. The identity of this material can be confirmed by energy dispersive X-ray spectrometry.
Image contributed by Dr. Ziad El-Zaatari - @ziad_zaatsri