Cutaneous minocycline hyperpigmentation
Minocycline is a tetracycline derivative antibiotic commonly prescribed for acne, rosacea, and other inflammatory skin disorders. Minocycline turns black when oxidized, leading to discoloration of the skin and nails. Pigmentation may also involve the bulbar conjunctiva, oral mucosa, teeth, bones, and thyroid gland. Pigmentation has been reported after long-term minocycline therapy with at least 100 mg/day.
Cutaneous minocycline hyperpigmentation is divided into 3 types; see last image. Type I is thought to be related to an iron chelate of minocycline Type II is probably secondary to a drug metabolite protein complex chelated with iron and calcium In Type III pigmentation is probably related to a photo drug induced dermatitis and melanin drop down from the basal layer
Images and text for 2nd paragraph contributed by Dr. Silvija Gottesman - @SGottesmanMD
Cutaneous minocycline hyperpigmentation
Minocycline is a tetracycline derivative antibiotic commonly prescribed for acne, rosacea, and other inflammatory skin disorders. Minocycline turns black when oxidized, leading to discoloration of the skin and nails. Pigmentation may also involve the bulbar conjunctiva, oral mucosa, teeth, bones, and thyroid gland. Pigmentation has been reported after long-term minocycline therapy with at least 100 mg/day.
Cutaneous minocycline hyperpigmentation is divided into 3 types; see last image. Type I is thought to be related to an iron chelate of minocycline Type II is probably secondary to a drug metabolite protein complex chelated with iron and calcium In Type III pigmentation is probably related to a photo drug induced dermatitis and melanin drop down from the basal layer
Images and text for 2nd paragraph contributed by Dr. Silvija Gottesman - @SGottesmanMD