Alpha synuclein ring-like oligomer interacting with the amyloid-beta peptide
Alpha synuclein ring-like oligomer interacting with the amyloid-beta peptide: Elucidation of the molecular mechanism of combined Parkinson’s and Alzheimer’s disease.
Authors: I. F. Tsigelny, Y. Sharikov, E. Masliah
The photograph shows interaction of the alpha-synuclein (aS) pentamer with amyloid-beta 1-42 peptide (orange) when penetrating to the cell membrane. Further penetration of the ring-like pentamer to the membrane leads to organization of the pore and farther uncontrolled influx of calcium ions leading to cell death. Presence of amyloid-beta peptide increases interaction of the pentamer with the membrane and consequently makes pores organization faster.
Alpha synuclein ring-like oligomer interacting with the amyloid-beta peptide
Alpha synuclein ring-like oligomer interacting with the amyloid-beta peptide: Elucidation of the molecular mechanism of combined Parkinson’s and Alzheimer’s disease.
Authors: I. F. Tsigelny, Y. Sharikov, E. Masliah
The photograph shows interaction of the alpha-synuclein (aS) pentamer with amyloid-beta 1-42 peptide (orange) when penetrating to the cell membrane. Further penetration of the ring-like pentamer to the membrane leads to organization of the pore and farther uncontrolled influx of calcium ions leading to cell death. Presence of amyloid-beta peptide increases interaction of the pentamer with the membrane and consequently makes pores organization faster.