dgg32
Presqualene cholesterol synthetic pathway
Porter 2010
Malformation syndromes caused by disorders of cholesterol synthesis www.ncbi.nlm.nih.gov/pubmed/20929975
Presqualene cholesterol synthetic pathway. Cholesterol is synthesized from acetate in a series of enzymatic reactions. The biosynthetic pathway can be divided into two components. The presqualene cholesterol synthetic pathway is depicted in this figure. In addition to cholesterol, isoprenoid precursors are used to synthesize heme A, dolichol, and ubiquinone. Protein prenylation is a post-translational modification that involves the addition of either farnesyl or geranylgeranyl. Protein prenylation plays a role in localizing proteins to cellular membranes. Formation of squalene represents a commitment to sterol synthesis. Squalene undergoes cyclization to form lanosterol, the first sterol in the cholesterol synthetic pathway. PP: pyrophosphate.
Presqualene cholesterol synthetic pathway
Porter 2010
Malformation syndromes caused by disorders of cholesterol synthesis www.ncbi.nlm.nih.gov/pubmed/20929975
Presqualene cholesterol synthetic pathway. Cholesterol is synthesized from acetate in a series of enzymatic reactions. The biosynthetic pathway can be divided into two components. The presqualene cholesterol synthetic pathway is depicted in this figure. In addition to cholesterol, isoprenoid precursors are used to synthesize heme A, dolichol, and ubiquinone. Protein prenylation is a post-translational modification that involves the addition of either farnesyl or geranylgeranyl. Protein prenylation plays a role in localizing proteins to cellular membranes. Formation of squalene represents a commitment to sterol synthesis. Squalene undergoes cyclization to form lanosterol, the first sterol in the cholesterol synthetic pathway. PP: pyrophosphate.