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Diagrammatic representation of the gastrodermis of female S. mansoni.
The diagram is based on an illustration originally published by Morris [52]. The illustration shows some highly enriched genes identified in this transcriptomic survey (Table 1, Table S3). Many of the genes products are putatively released into, or onto the membrane of epicellular vacuoles (EV) present at the luminal surface of the syncytial epithelium. Three EVs are depicted (EV1–3), each showing different physiological activities proposed to occur in the vacuoles. EV1 depicts haemoglobinolysis pathways. Many proteases are released into the EV, resulting in catabolism of haemoglobin into amino acids or small peptides for uptake. Haem, a byproduct of catabolism, is sequestered into haematin (see illustration in [53]) for subsequent egestion. EV2 depicts a potential series of molecules associated with lysosomal functions, which has been transferred to these vacuolar compartments. EV3 shows a series of membrane proteins, involved in a variety of functions, notably transmembrane transport of metabolites, which would be preferentially associated with the epicellular vacuoles. All three physiological activities may occur in the same vacuole, probably concurrently.
Taken from: www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.p...
doi:10.1371/journal.pntd.0001043.g003
Diagrammatic representation of the gastrodermis of female S. mansoni.
The diagram is based on an illustration originally published by Morris [52]. The illustration shows some highly enriched genes identified in this transcriptomic survey (Table 1, Table S3). Many of the genes products are putatively released into, or onto the membrane of epicellular vacuoles (EV) present at the luminal surface of the syncytial epithelium. Three EVs are depicted (EV1–3), each showing different physiological activities proposed to occur in the vacuoles. EV1 depicts haemoglobinolysis pathways. Many proteases are released into the EV, resulting in catabolism of haemoglobin into amino acids or small peptides for uptake. Haem, a byproduct of catabolism, is sequestered into haematin (see illustration in [53]) for subsequent egestion. EV2 depicts a potential series of molecules associated with lysosomal functions, which has been transferred to these vacuolar compartments. EV3 shows a series of membrane proteins, involved in a variety of functions, notably transmembrane transport of metabolites, which would be preferentially associated with the epicellular vacuoles. All three physiological activities may occur in the same vacuole, probably concurrently.
Taken from: www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.p...
doi:10.1371/journal.pntd.0001043.g003