The Why Files
Prosek_Hailey1
Image by Hailey Prosek, Undergraduate Student Researcher, Kling and Pattnaik Labs, Department of Pediatrics
This image of the glomeruli, proximal tubules, and distal tubules of fetal sheep kidneys was taken via immunohistochemistry with fluorescence. Red fluorescence indicates the Angiotensin-II (AT2R) receptor, whereas the green fluorescence indicates megalin, a scavenger protein that carries other receptors into the cell. Colocalization is indicated by yellow fluorescence, meaning that the two receptors are at the same place at the same time. Sheep are a commonly used model for reduced space in the uterus on offspring, so images such as this aid our research into kidney development and function under the condition of intrauterine growth restriction (IUGR), where the fetus does not grow to his/her potential. IUGR is important to study because it can cause kidney dysfunction and high blood pressure during childhood and young adulthood. These images aid in our exploration of potential preventative measures and treatments for kidney dysfunction and high blood pressure in previously IUGR humans.
Prosek_Hailey1
Image by Hailey Prosek, Undergraduate Student Researcher, Kling and Pattnaik Labs, Department of Pediatrics
This image of the glomeruli, proximal tubules, and distal tubules of fetal sheep kidneys was taken via immunohistochemistry with fluorescence. Red fluorescence indicates the Angiotensin-II (AT2R) receptor, whereas the green fluorescence indicates megalin, a scavenger protein that carries other receptors into the cell. Colocalization is indicated by yellow fluorescence, meaning that the two receptors are at the same place at the same time. Sheep are a commonly used model for reduced space in the uterus on offspring, so images such as this aid our research into kidney development and function under the condition of intrauterine growth restriction (IUGR), where the fetus does not grow to his/her potential. IUGR is important to study because it can cause kidney dysfunction and high blood pressure during childhood and young adulthood. These images aid in our exploration of potential preventative measures and treatments for kidney dysfunction and high blood pressure in previously IUGR humans.