Ranarupta
Slide27
“Canine Thyroglobulin Autoantibodies (TgAA)
An estimated 80% of cases of canine hypothyroidism result from heritable autoimmune (lymphocytic) thyroiditis. Many popular breeds are at increased risk for this disorder, with English Setters being the breed exhibiting the highest prevalence of thyroiditis today (>40% of those tested).
The presence of elevated TgAA levels confirms thyroiditis, promotes early recognition of the disorder, and facilitates genetic counseling. Low-grade false positive results can occur if the dog has been vaccinated recently, especially with rabies vaccine; retesting is recommended in 90 days. False negative results can occur in up to 8% of T3AA and/or T4AA confirmed positive thyroiditis cases, presumably because not all epitopes of TgAA are recognized by the assay reagent. Dogs on thyroid supplement should be off this medication for at least 90 days to obtain accurate TgAA results. Please note that reporting units for the TgAA normal reference range have changed recently from <200% to <20%. All equivocal or positive results are repeated with a confirmatory test to correct for non-specific binding (NSB TgAA); the normal reference range for this confirmatory test is <10%.”
Excerpt from Antech Diagnostics newsletter, November, 2005. Retrieved April 10, 2010 from: www.antechdiagnostics.com/
* I would not repeat this statement verbatim, I have it quoted here so I can remember the main points of the test. If someone asks a question about this test, I can refer to these notes.
Slide27
“Canine Thyroglobulin Autoantibodies (TgAA)
An estimated 80% of cases of canine hypothyroidism result from heritable autoimmune (lymphocytic) thyroiditis. Many popular breeds are at increased risk for this disorder, with English Setters being the breed exhibiting the highest prevalence of thyroiditis today (>40% of those tested).
The presence of elevated TgAA levels confirms thyroiditis, promotes early recognition of the disorder, and facilitates genetic counseling. Low-grade false positive results can occur if the dog has been vaccinated recently, especially with rabies vaccine; retesting is recommended in 90 days. False negative results can occur in up to 8% of T3AA and/or T4AA confirmed positive thyroiditis cases, presumably because not all epitopes of TgAA are recognized by the assay reagent. Dogs on thyroid supplement should be off this medication for at least 90 days to obtain accurate TgAA results. Please note that reporting units for the TgAA normal reference range have changed recently from <200% to <20%. All equivocal or positive results are repeated with a confirmatory test to correct for non-specific binding (NSB TgAA); the normal reference range for this confirmatory test is <10%.”
Excerpt from Antech Diagnostics newsletter, November, 2005. Retrieved April 10, 2010 from: www.antechdiagnostics.com/
* I would not repeat this statement verbatim, I have it quoted here so I can remember the main points of the test. If someone asks a question about this test, I can refer to these notes.