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Efbemalenograstim Alfa Solution CAS 2200269‑79‑8 | Research‑Grade Long‑Acting G‑CSF (dimeric)
Product Description
Efbemalenograstim Alfa Solution (CAS 2200269‑79‑8) is a high-purity, recombinant, long-acting G-CSF fusion protein designed exclusively for laboratory and mechanistic research. Structurally, it consists of a dimer of human G-CSF molecules linked to a human IgG2 Fc fragment, forming a stable dimeric configuration that prolongs protein half-life through Fc-mediated recycling. This extended stability allows sustained receptor engagement, enabling precise studies of granulopoiesis, signal transduction, and progenitor cell proliferation under controlled experimental conditions.
In vitro and ex vivo models benefit from the prolonged G-CSF receptor activation provided by Efbemalenograstim Alfa, as it supports extended JAK/STAT signaling, particularly STAT3 and STAT5 phosphorylation. Researchers can monitor downstream transcriptional responses, anti-apoptotic gene expression, and differentiation kinetics in primary hematopoietic progenitor cells. The sterile solution format eliminates variability associated with lyophilized reconstitution, ensuring reproducible concentrations and reliable mechanistic observations in cell culture systems.
The design of Efbemalenograstim Alfa allows investigators to model long-term granulopoiesis, examine receptor internalization, and study feedback regulation of the G-CSF signaling pathway.
Efbemalenograstim Alfa Solution CAS 2200269‑79‑8 | Research‑Grade Long‑Acting G‑CSF (dimeric)
Product Description
Efbemalenograstim Alfa Solution (CAS 2200269‑79‑8) is a high-purity, recombinant, long-acting G-CSF fusion protein designed exclusively for laboratory and mechanistic research. Structurally, it consists of a dimer of human G-CSF molecules linked to a human IgG2 Fc fragment, forming a stable dimeric configuration that prolongs protein half-life through Fc-mediated recycling. This extended stability allows sustained receptor engagement, enabling precise studies of granulopoiesis, signal transduction, and progenitor cell proliferation under controlled experimental conditions.
In vitro and ex vivo models benefit from the prolonged G-CSF receptor activation provided by Efbemalenograstim Alfa, as it supports extended JAK/STAT signaling, particularly STAT3 and STAT5 phosphorylation. Researchers can monitor downstream transcriptional responses, anti-apoptotic gene expression, and differentiation kinetics in primary hematopoietic progenitor cells. The sterile solution format eliminates variability associated with lyophilized reconstitution, ensuring reproducible concentrations and reliable mechanistic observations in cell culture systems.
The design of Efbemalenograstim Alfa allows investigators to model long-term granulopoiesis, examine receptor internalization, and study feedback regulation of the G-CSF signaling pathway.