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Fosaprepitant Dimeglumine | CAS 265121-04-8 | NK1 Receptor Antagonist Prodrug for Neurokinin Pathway Research
Product Description
Fosaprepitant Dimeglumine (CAS 265121-04-8) is a phosphorylated prodrug of aprepitant extensively used in preclinical research to investigate NK1 receptor-mediated signaling, neurokinin pathways, and cytokine modulation. Fosaprepitant Dimeglumine’s lyophilized powder form provides enhanced solubility, precise dosing, and reproducibility in both in vitro and in vivo assays.
Pharmacological Background
The NK1 receptor is a G-protein-coupled receptor (GPCR) expressed in central and peripheral nervous systems, immune cells, and epithelial tissues. Its primary endogenous ligand, Substance P, mediates neurogenic inflammation, neurotransmission, and immune modulation. Fosaprepitant Dimeglumine, once enzymatically dephosphorylated, converts to aprepitant, a selective NK1 receptor antagonist, making it a reliable tool to study receptor desensitization, ligand binding kinetics, and downstream MAPK/ERK, JNK, and p38 signaling pathways.
Fosaprepitant Dimeglumine is widely used to explore:
Neuroimmune interactions and cytokine modulation (IL-1β, IL-6, TNF-α)
Central and peripheral nervous system stress responses
GPCR-mediated intracellular calcium signaling
MAPK/ERK, JNK, and p38 signal transduction
Receptor internalization and desensitization
Neuroinflammatory and oxidative stress models
Research Applications
Fosaprepitant Dimeglumine is applied in molecular, cellular, and pharmacological studies.
Fosaprepitant Dimeglumine | CAS 265121-04-8 | NK1 Receptor Antagonist Prodrug for Neurokinin Pathway Research
Product Description
Fosaprepitant Dimeglumine (CAS 265121-04-8) is a phosphorylated prodrug of aprepitant extensively used in preclinical research to investigate NK1 receptor-mediated signaling, neurokinin pathways, and cytokine modulation. Fosaprepitant Dimeglumine’s lyophilized powder form provides enhanced solubility, precise dosing, and reproducibility in both in vitro and in vivo assays.
Pharmacological Background
The NK1 receptor is a G-protein-coupled receptor (GPCR) expressed in central and peripheral nervous systems, immune cells, and epithelial tissues. Its primary endogenous ligand, Substance P, mediates neurogenic inflammation, neurotransmission, and immune modulation. Fosaprepitant Dimeglumine, once enzymatically dephosphorylated, converts to aprepitant, a selective NK1 receptor antagonist, making it a reliable tool to study receptor desensitization, ligand binding kinetics, and downstream MAPK/ERK, JNK, and p38 signaling pathways.
Fosaprepitant Dimeglumine is widely used to explore:
Neuroimmune interactions and cytokine modulation (IL-1β, IL-6, TNF-α)
Central and peripheral nervous system stress responses
GPCR-mediated intracellular calcium signaling
MAPK/ERK, JNK, and p38 signal transduction
Receptor internalization and desensitization
Neuroinflammatory and oxidative stress models
Research Applications
Fosaprepitant Dimeglumine is applied in molecular, cellular, and pharmacological studies.