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Doxifluridine | CAS 3094-09-5 | Nucleoside Analog for Cancer Research
Product Description
Doxifluridine is a fluorinated pyrimidine nucleoside analog developed for laboratory research to explore anticancer mechanisms, DNA replication inhibition, and nucleotide metabolism. As a prodrug of 5-fluorouracil, doxifluridine undergoes intracellular enzymatic conversion to release 5-FU, which is subsequently phosphorylated to its active nucleotide forms. These metabolites incorporate into RNA and DNA, disrupt nucleic acid synthesis, and inhibit thymidylate synthase, leading to S-phase cell cycle arrest and apoptotic pathways activation.
Researchers utilize doxifluridine to investigate the cellular response to nucleotide pool imbalance, DNA damage, and replication stress in various tumor cell lines. Its fluorinated structure enhances lipophilicity and oral bioavailability in vivo, but in laboratory research, it provides a controlled model for studying 5-FU-related cytotoxicity without direct administration of 5-FU. This makes it a valuable tool for mechanistic studies on drug metabolism, enzyme activation, and tumor cell sensitivity.
Experimental studies demonstrate that doxifluridine can modulate gene expression related to DNA repair, apoptosis, and nucleotide metabolism. Its activity is observed in both rapidly proliferating cancer cells and in models simulating chemotherapeutic resistance.
Doxifluridine | CAS 3094-09-5 | Nucleoside Analog for Cancer Research
Product Description
Doxifluridine is a fluorinated pyrimidine nucleoside analog developed for laboratory research to explore anticancer mechanisms, DNA replication inhibition, and nucleotide metabolism. As a prodrug of 5-fluorouracil, doxifluridine undergoes intracellular enzymatic conversion to release 5-FU, which is subsequently phosphorylated to its active nucleotide forms. These metabolites incorporate into RNA and DNA, disrupt nucleic acid synthesis, and inhibit thymidylate synthase, leading to S-phase cell cycle arrest and apoptotic pathways activation.
Researchers utilize doxifluridine to investigate the cellular response to nucleotide pool imbalance, DNA damage, and replication stress in various tumor cell lines. Its fluorinated structure enhances lipophilicity and oral bioavailability in vivo, but in laboratory research, it provides a controlled model for studying 5-FU-related cytotoxicity without direct administration of 5-FU. This makes it a valuable tool for mechanistic studies on drug metabolism, enzyme activation, and tumor cell sensitivity.
Experimental studies demonstrate that doxifluridine can modulate gene expression related to DNA repair, apoptosis, and nucleotide metabolism. Its activity is observed in both rapidly proliferating cancer cells and in models simulating chemotherapeutic resistance.