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Nonapeptide-1 acetate | CAS 158563-45-2 | Melanin-Inhibiting Peptide for Skin Brightening and Pigmentation Research
Product Description
Nonapeptide-1 acetate, also known as Melanostatine-5 acetate salt, is a synthetic peptide hormone designed for modulating melanogenesis and regulating skin pigmentation. It acts as a highly selective antagonist of the melanocortin-1 receptor (MC1R), effectively inhibiting α-MSH-mediated signaling in melanocytes. This inhibition results in decreased intracellular cAMP levels, reduced melanosome dispersion, and a significant suppression of melanin synthesis, making it a prominent tool in skin brightening and anti-pigmentation research.
In dermatological research, Nonapeptide-1 acetate is recognized for its potent melanin inhibition activity. By competing with α-MSH, it modulates the enzymatic machinery involved in melanin production, ultimately reducing hyperpigmentation, age spots, and uneven skin tone in in vitro and ex vivo models. This selective antagonism enables researchers to explore the molecular mechanisms of melanogenesis and evaluate the efficacy of new cosmetic formulations for skin lightening.
The peptide’s molecular composition, consisting of nine amino acids (nonapeptide), allows for efficient dermal penetration and stability, making it compatible with topical cosmetic studies. Its small size ensures high bioavailability in skin tissue, which is critical for evaluating pigmentation modulation, melanocyte activity, and related enzymatic pathways.
arizona-mall.com/product/nonapeptide-1-acetate-cas-158563...
Nonapeptide-1 acetate | CAS 158563-45-2 | Melanin-Inhibiting Peptide for Skin Brightening and Pigmentation Research
Product Description
Nonapeptide-1 acetate, also known as Melanostatine-5 acetate salt, is a synthetic peptide hormone designed for modulating melanogenesis and regulating skin pigmentation. It acts as a highly selective antagonist of the melanocortin-1 receptor (MC1R), effectively inhibiting α-MSH-mediated signaling in melanocytes. This inhibition results in decreased intracellular cAMP levels, reduced melanosome dispersion, and a significant suppression of melanin synthesis, making it a prominent tool in skin brightening and anti-pigmentation research.
In dermatological research, Nonapeptide-1 acetate is recognized for its potent melanin inhibition activity. By competing with α-MSH, it modulates the enzymatic machinery involved in melanin production, ultimately reducing hyperpigmentation, age spots, and uneven skin tone in in vitro and ex vivo models. This selective antagonism enables researchers to explore the molecular mechanisms of melanogenesis and evaluate the efficacy of new cosmetic formulations for skin lightening.
The peptide’s molecular composition, consisting of nine amino acids (nonapeptide), allows for efficient dermal penetration and stability, making it compatible with topical cosmetic studies. Its small size ensures high bioavailability in skin tissue, which is critical for evaluating pigmentation modulation, melanocyte activity, and related enzymatic pathways.
arizona-mall.com/product/nonapeptide-1-acetate-cas-158563...