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Palopegteriparatide | CAS 2222514-07-8 | Long-Acting PTH Prodrug for Hypoparathyroidism Research
Product Description
Palopegteriparatide, also known as Transcon PTH, represents an advanced form of parathyroid hormone replacement designed for long-term regulation of calcium homeostasis. As a PTH 1-34 prodrug, it utilizes a sustained-release linker system that gradually releases active PTH in circulation, providing stable hormonal activity that closely mimics natural secretion patterns.This compound plays a pivotal role in laboratory research on calcium metabolism, bone remodeling, and parathyroid gland disorders. Unlike conventional peptide PTH analogs requiring frequent administration, Palopegteriparatide ensures prolonged bioavailability and consistent serum calcium maintenance. Its controlled activation eliminates the need for additional calcium or vitamin D supplementation, a breakthrough in experimental models of chronic hypoparathyroidism.Researchers employ Palopegteriparatide to study molecular pathways regulating bone formation, renal calcium reabsorption, and phosphate balance. The compound has also been valuable in understanding endocrine feedback mechanisms and receptor desensitization under sustained PTH exposure. With its unique pharmacokinetic profile, Palopegteriparatide offers a superior platform for investigating long-term PTH signaling, calcium transport, and systemic mineral metabolism.
Mechanism of Action
Palopegteriparatide functions as a transiently bound prodrug of parathyroid hormone fragment PTH 1-34.
arizona-mall.com/product/palopegteriparatide-cas-2222514-...
Palopegteriparatide | CAS 2222514-07-8 | Long-Acting PTH Prodrug for Hypoparathyroidism Research
Product Description
Palopegteriparatide, also known as Transcon PTH, represents an advanced form of parathyroid hormone replacement designed for long-term regulation of calcium homeostasis. As a PTH 1-34 prodrug, it utilizes a sustained-release linker system that gradually releases active PTH in circulation, providing stable hormonal activity that closely mimics natural secretion patterns.This compound plays a pivotal role in laboratory research on calcium metabolism, bone remodeling, and parathyroid gland disorders. Unlike conventional peptide PTH analogs requiring frequent administration, Palopegteriparatide ensures prolonged bioavailability and consistent serum calcium maintenance. Its controlled activation eliminates the need for additional calcium or vitamin D supplementation, a breakthrough in experimental models of chronic hypoparathyroidism.Researchers employ Palopegteriparatide to study molecular pathways regulating bone formation, renal calcium reabsorption, and phosphate balance. The compound has also been valuable in understanding endocrine feedback mechanisms and receptor desensitization under sustained PTH exposure. With its unique pharmacokinetic profile, Palopegteriparatide offers a superior platform for investigating long-term PTH signaling, calcium transport, and systemic mineral metabolism.
Mechanism of Action
Palopegteriparatide functions as a transiently bound prodrug of parathyroid hormone fragment PTH 1-34.
arizona-mall.com/product/palopegteriparatide-cas-2222514-...