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Exendin 4, Biotin Labeled | Long-acting GLP-1 Receptor Agonist for Endocrine and Metabolic Research
Product Description
Exendin 4, Biotin Labeled is a chemically modified analog of Exendin 4 (HY-13443), a potent and selective glucagon-like peptide-1 receptor (GLP-1R) agonist. Derived from the natural exendin sequence found in the saliva of the Gila monster (Heloderma suspectum), this biotinylated version retains full receptor activity while incorporating a biotin moiety that allows easy conjugation to streptavidin-based detection systems.
This modification expands its versatility for use in receptor binding assays, ligand-receptor mapping, fluorescence imaging, and high-throughput screening (HTS) of GLP-1–targeted compounds. Researchers often utilize Exendin 4, Biotin Labeled to visualize and quantify GLP-1 receptor expression, study receptor internalization pathways, and monitor ligand-induced signaling events.
As a long-acting GLP-1 receptor agonist, Exendin 4 mimics the biological actions of endogenous GLP-1 but exhibits enhanced stability and prolonged receptor activation, due to its resistance to enzymatic degradation by dipeptidyl peptidase-4 (DPP-4). It plays a crucial role in the regulation of glucose metabolism, insulin secretion, appetite control, and β-cell survival.
The biotin labeling does not significantly alter its binding affinity or activity, allowing researchers to use it as a functional probe in receptor-ligand studies or in pull-down assays to isolate GLP-1R complexes.
Exendin 4, Biotin Labeled | Long-acting GLP-1 Receptor Agonist for Endocrine and Metabolic Research
Product Description
Exendin 4, Biotin Labeled is a chemically modified analog of Exendin 4 (HY-13443), a potent and selective glucagon-like peptide-1 receptor (GLP-1R) agonist. Derived from the natural exendin sequence found in the saliva of the Gila monster (Heloderma suspectum), this biotinylated version retains full receptor activity while incorporating a biotin moiety that allows easy conjugation to streptavidin-based detection systems.
This modification expands its versatility for use in receptor binding assays, ligand-receptor mapping, fluorescence imaging, and high-throughput screening (HTS) of GLP-1–targeted compounds. Researchers often utilize Exendin 4, Biotin Labeled to visualize and quantify GLP-1 receptor expression, study receptor internalization pathways, and monitor ligand-induced signaling events.
As a long-acting GLP-1 receptor agonist, Exendin 4 mimics the biological actions of endogenous GLP-1 but exhibits enhanced stability and prolonged receptor activation, due to its resistance to enzymatic degradation by dipeptidyl peptidase-4 (DPP-4). It plays a crucial role in the regulation of glucose metabolism, insulin secretion, appetite control, and β-cell survival.
The biotin labeling does not significantly alter its binding affinity or activity, allowing researchers to use it as a functional probe in receptor-ligand studies or in pull-down assays to isolate GLP-1R complexes.