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Protein Kinase C β Peptide | CAS 309247-50-5 | Protein Kinase Cβ Fragment for Vascular Research
Product Description
Protein Kinase C β Peptide (CAS 309247-50-5) is a research-grade peptide derived from the β isoform of Protein Kinase C (PKCβ), a member of the serine/threonine kinase family that plays a crucial role in cellular signal transduction. PKCβ is activated by diacylglycerol and calcium ions and is intimately involved in modulating vascular tone, inflammation, and endothelial function.
This peptide fragment represents a functional domain of PKCβ that can be used in studies investigating kinase regulation, phosphorylation events, and downstream signaling mechanisms. Hyperglycemia has been shown to activate PKCβ, leading to endothelial dysfunction through the reduction of nitric oxide bioavailability. The use of PKCβ inhibitors—or its peptide analogs—has demonstrated the ability to restore normal endothelial-dependent vasodilation in experimental models.
Protein Kinase C β Peptide serves as a powerful research tool for exploring the molecular basis of vascular complications in diabetes, including retinopathy, nephropathy, and atherosclerosis. Researchers employ this peptide to dissect the complex interactions between PKCβ signaling and nitric oxide synthase pathways.
Beyond vascular studies, PKCβ is also implicated in immune responses, cell proliferation, and apoptosis. The peptide fragment can be used to map phosphorylation targets or design selective inhibitors for therapeutic exploration.
Protein Kinase C β Peptide | CAS 309247-50-5 | Protein Kinase Cβ Fragment for Vascular Research
Product Description
Protein Kinase C β Peptide (CAS 309247-50-5) is a research-grade peptide derived from the β isoform of Protein Kinase C (PKCβ), a member of the serine/threonine kinase family that plays a crucial role in cellular signal transduction. PKCβ is activated by diacylglycerol and calcium ions and is intimately involved in modulating vascular tone, inflammation, and endothelial function.
This peptide fragment represents a functional domain of PKCβ that can be used in studies investigating kinase regulation, phosphorylation events, and downstream signaling mechanisms. Hyperglycemia has been shown to activate PKCβ, leading to endothelial dysfunction through the reduction of nitric oxide bioavailability. The use of PKCβ inhibitors—or its peptide analogs—has demonstrated the ability to restore normal endothelial-dependent vasodilation in experimental models.
Protein Kinase C β Peptide serves as a powerful research tool for exploring the molecular basis of vascular complications in diabetes, including retinopathy, nephropathy, and atherosclerosis. Researchers employ this peptide to dissect the complex interactions between PKCβ signaling and nitric oxide synthase pathways.
Beyond vascular studies, PKCβ is also implicated in immune responses, cell proliferation, and apoptosis. The peptide fragment can be used to map phosphorylation targets or design selective inhibitors for therapeutic exploration.