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Excitin 1 | CAS 17136-25-3 | CNS-Penetrating Neuroactive Peptide Modulating Monoamine Neurotransmission
Product Description
Excitin 1 (CAS 17136-25-3) is a bioactive central nervous system (CNS) peptide characterized by its ability to penetrate the blood-brain barrier and modulate neurochemical homeostasis. Unlike many neuropeptides that are rapidly degraded in the gastrointestinal tract or unable to access the CNS, Excitin 1 demonstrates oral bioavailability and robust CNS permeability, making it a rare and significant model compound for brain-targeted peptide research.
As a neuromodulatory peptide, Excitin 1 alters the concentrations of monoamines (dopamine, serotonin, norepinephrine) and amino acids (glutamate, GABA, aspartate, glycine) within specific brain regions. These biochemical alterations correspond to measurable behavioral changes in experimental animals, suggesting a profound impact on neuronal communication and synaptic plasticity.
Excitin 1 has been explored in preclinical models for its ability to influence mood, cognition, arousal, and motor function, positioning it as a potential lead compound for developing new neuropsychiatric and neuroprotective agents. Research indicates that Excitin 1 may regulate monoaminergic pathways in the hypothalamus, striatum, and hippocampus, producing both stimulatory and modulatory effects depending on dosage and timing.
In rat models, administration of Excitin 1 leads to dose-dependent behavioral activation, accompanied by changes in dopamine turnover and serotonin metabolism.
Excitin 1 | CAS 17136-25-3 | CNS-Penetrating Neuroactive Peptide Modulating Monoamine Neurotransmission
Product Description
Excitin 1 (CAS 17136-25-3) is a bioactive central nervous system (CNS) peptide characterized by its ability to penetrate the blood-brain barrier and modulate neurochemical homeostasis. Unlike many neuropeptides that are rapidly degraded in the gastrointestinal tract or unable to access the CNS, Excitin 1 demonstrates oral bioavailability and robust CNS permeability, making it a rare and significant model compound for brain-targeted peptide research.
As a neuromodulatory peptide, Excitin 1 alters the concentrations of monoamines (dopamine, serotonin, norepinephrine) and amino acids (glutamate, GABA, aspartate, glycine) within specific brain regions. These biochemical alterations correspond to measurable behavioral changes in experimental animals, suggesting a profound impact on neuronal communication and synaptic plasticity.
Excitin 1 has been explored in preclinical models for its ability to influence mood, cognition, arousal, and motor function, positioning it as a potential lead compound for developing new neuropsychiatric and neuroprotective agents. Research indicates that Excitin 1 may regulate monoaminergic pathways in the hypothalamus, striatum, and hippocampus, producing both stimulatory and modulatory effects depending on dosage and timing.
In rat models, administration of Excitin 1 leads to dose-dependent behavioral activation, accompanied by changes in dopamine turnover and serotonin metabolism.