Lorlatinib Tablets 25mg (Lorbrena®) – Instructions

Lorlatinib Product Specifications

 

 

Attribute

Details

 

 

Product Name

Lorlatinib Tablets (Lorbrena®)

 

 

Generic Name

Lorlatinib

 

 

Dosage Form

Oral film-coated tablet

 

 

Strength

25mg per tablet

 

 

Packaging

90 tablets per box

 

 

Approval Number

China NMPA HJ20220040

 

 

Product Code

86982879000049

 

 

Manufacturer

Pfizer Manufacturing Deutschland GmbH

 

 

Brand Name

Lorbrena®

 

 

Molecular Formula

C??H??FN?O?

 

 

Molecular Weight

406.41?g/mol

 

 

CAS Number

1454846?35?5

 

 

Bioavailability

81%

 

 

Protein Binding

66%

 

 

Half-life

~24?hours

 

 

Metabolism

CYP3A4/UGT1A4

 

 

Excretion

48% urine, 41% feces

 

 

Intended Use

Laboratory research only — Not for clinical or veterinary use

 

 

Lorlatinib Mechanism of Action

Lorlatinib is a potent, selective inhibitor of ALK and ROS1 tyrosine kinases, including resistant mutants. It reversibly binds the ATP-pocket, blocking downstream PI3K/Akt/mTOR and RAS/RAF/MEK/ERK signaling. Its macrocyclic structure grants CNS penetration, improving efficacy against brain metastases ncbi.nlm.nih.gov+11pfizermedicalinformation.cn+11synapse.patsnap.com+11.

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