isev2
SCIJR4
Catch me if you can. The direct visualization of EV uptake events is challenging but could help us to better understand and/or validate specific endocytosis pathway used by receiving cells to internalize EVs. Here we show an electron microscopy image of an EV coming from 4T1 cell line, in the vicinity of the plasma membrane of another 4T1 cell. An invagination of the plasma membrane as well as a membrane protrusion of the 4T1 cell are both engaged in the capture of an EV. This image could illustrate the first steps of EV internalization by receiving cells, likely through the macropinocytosis pathway. Scale bar: 500µm
SCIJR4
Catch me if you can. The direct visualization of EV uptake events is challenging but could help us to better understand and/or validate specific endocytosis pathway used by receiving cells to internalize EVs. Here we show an electron microscopy image of an EV coming from 4T1 cell line, in the vicinity of the plasma membrane of another 4T1 cell. An invagination of the plasma membrane as well as a membrane protrusion of the 4T1 cell are both engaged in the capture of an EV. This image could illustrate the first steps of EV internalization by receiving cells, likely through the macropinocytosis pathway. Scale bar: 500µm