Alzheimer Europe Conference
POS2.4 Efthymiopoulou Efthymia-Effects of holistic program on cognitive function and CSF neurodegenerative biomarkers in Alzheimer’s disease
Main Author: Efthymia Efthymiopoulou, IASIS NGO - Co-Authors: Stavroula Pantinaki & Polyxeni Giannaki & Vassileios Malamatenios & Anastasia Bougea
Objective: Our study aimed to assess the effect of a 12-month holistic program on cognitive function and cerebrospinal fluid (CSF) amyloid beta (Aβ)- tau related biomarkers in subjects with Alzheimer’s disease (AD).
Methods: This was a randomized, double-blind, placebo-controlled trial from 2 Greek geriatric clinics Maison Sofos and General Hospital of Santorini. 40 AD subjects were randomly divided into intervention and usual care groups. Participants received 12-month 1000 IU/day of vitamin D or starch granules as placebo, cognitive empowerment and yoga exercise twice/week. Cognitive assessment included Hopkins verbal learning test, Stroop test, Trail Making Test (A&B), Frontal assessment battery, clock drawing test, Geriatric Depression Scale, Brief Visual Memory Test. Aβ-related biomarkers were measured at baseline, 6 months and 12 months.
Results: Significant lower CSF Aβ42 and tau levels were found in the intervention group over the control group after 12 months follow-up(p<0.001). Significant lower scores in Hopkins verbal learning test, Stroop test, Trail Making Test (A&B), Frontal assessment battery, clock drawing test, Geriatric Depression Scale, Brief Visual Memory Test intervention group over the control group after 6 months follow-up(p<0.001). According to mixed-model analysis, intervention group had a significant improvement in Hopkins verbal learning test scale during the 12month follow-up period (p<0.001)
Conclusions The proposed holistic program significantly improved the cognitive function, mood and neurochemical status, and the positive changes were maintained at the 3-month endpoints in subjects with AD. Larger scale longitudes trials are needed to confirm these results.
POS2.4 Efthymiopoulou Efthymia-Effects of holistic program on cognitive function and CSF neurodegenerative biomarkers in Alzheimer’s disease
Main Author: Efthymia Efthymiopoulou, IASIS NGO - Co-Authors: Stavroula Pantinaki & Polyxeni Giannaki & Vassileios Malamatenios & Anastasia Bougea
Objective: Our study aimed to assess the effect of a 12-month holistic program on cognitive function and cerebrospinal fluid (CSF) amyloid beta (Aβ)- tau related biomarkers in subjects with Alzheimer’s disease (AD).
Methods: This was a randomized, double-blind, placebo-controlled trial from 2 Greek geriatric clinics Maison Sofos and General Hospital of Santorini. 40 AD subjects were randomly divided into intervention and usual care groups. Participants received 12-month 1000 IU/day of vitamin D or starch granules as placebo, cognitive empowerment and yoga exercise twice/week. Cognitive assessment included Hopkins verbal learning test, Stroop test, Trail Making Test (A&B), Frontal assessment battery, clock drawing test, Geriatric Depression Scale, Brief Visual Memory Test. Aβ-related biomarkers were measured at baseline, 6 months and 12 months.
Results: Significant lower CSF Aβ42 and tau levels were found in the intervention group over the control group after 12 months follow-up(p<0.001). Significant lower scores in Hopkins verbal learning test, Stroop test, Trail Making Test (A&B), Frontal assessment battery, clock drawing test, Geriatric Depression Scale, Brief Visual Memory Test intervention group over the control group after 6 months follow-up(p<0.001). According to mixed-model analysis, intervention group had a significant improvement in Hopkins verbal learning test scale during the 12month follow-up period (p<0.001)
Conclusions The proposed holistic program significantly improved the cognitive function, mood and neurochemical status, and the positive changes were maintained at the 3-month endpoints in subjects with AD. Larger scale longitudes trials are needed to confirm these results.