Schematic diagram of the various applications of glycan arrays relating to applications

Screening protein and antibody interactions with various glycans, virus and bacteria interactions with glycoproteins; and interactions of mammalian cells with glycosaminoglycan structures which lead to live cell responses relating to phosphorylation of cell signaling cascades. Symbols for glycan structures use nomenclature from [1]. Yellow circles: galactose; yellow squares: N-acetylgalactosamine; blue squares: N-acetylglucosamine; green circles: mannose; blue/white diamonds: glucuronic acid; brown/white diamond: iduronic acid; sulphation shown by 2S, 6S and NS; extra lines on the diamond represent unsaturated bonds.

1. Varki, A.; Cummings, R.D.; Esko, J.D.; Freeze, H.H.; Stanley, P.; Marth, J.D.; Bertozzi, C.R.; Hart, G.W.; Etzler, M.E. Symbol nomenclature for glycan representation. Proteomics 2009, 9, 5398–5399.

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Uploaded on May 14, 2020