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Pleural Mesothelioma Symptoms - Asbestos exposure disease
via Cancer Mesothelioma Lawyer - Attorneys, Stages and treatments ift.tt/2QbKcsC
Pleural mesothelioma is a malignant neoplasm of the pleura, strongly associated with occupational exposure to asbestos (or asbestos).
Most common pleural mesothelioma symptoms
Asbestos fibers are extremely thin and penetrate through the respiratory tract. At the level of the pulmonary alveoli, the inhaled particles trigger an immune response: the macrophages absorb these foreign bodies and release local cytokines and growth factors that stimulate an inflammatory reaction. This leads to the deposition of collagen and, finally, to interstitial fibrosis (asbestosis).
Asbestos fibers may also exert a direct toxic and indirectly mutagenic effect on the pleura and pulmonary tissue. The time between exposure to asbestos and the appearance of mesothelioma can be very long, in the order of a few decades.
Other factors that may predispose to the development of this neoplasm are some genetic alterations, chest irradiation and previous pulmonary infections (especially those sustained by the SV40 virus).
Further information
Mesothelioma can grow locally or metastasize to lymph nodes, heart, peritoneum, liver, and kidney. At the onset, the symptoms are rare. As the disease progresses, dyspnoea and chest pain appear, and a nodular thickening of the pleura is found. Invasion of the chest wall and involvement of neighboring structures may result in a persistent cough, fever, weight loss, sweating, hoarseness, dysphagia, paralysis of the vocal cords, abdominal pain and ascites. In most cases, there are deposits in the space between the two pleural sheets, typically monolateral, large and hemorrhagic.
Long-term survival is rare.
The assessment of mesothelioma involves a thorough medical history, with particular attention to occupational exposure to asbestos fibers, a complete physical examination and chest radiography.
Often, this tumor is difficult to diagnose and usually requires a pleural biopsy or cytological examination of the pleural fluid. Staging is performed with a chest CT scan, mediastinoscopy, and magnetic resonance imaging.
Unfortunately, pleural mesothelioma is a very aggressive malignant tumor: surgical and chemotherapeutic options have limited benefits and often do not significantly prolong survival. The main goals of therapy are pain relief and pleural effusion dyspnea by pleurodesis or pleurectomy. If the neoplasm is at an early stage, surgical resection of the tumor mass may be attempted.
4.90/5 – 1289
Pleural Mesothelioma Symptoms - Asbestos exposure disease
via Cancer Mesothelioma Lawyer - Attorneys, Stages and treatments ift.tt/2QbKcsC
Pleural mesothelioma is a malignant neoplasm of the pleura, strongly associated with occupational exposure to asbestos (or asbestos).
Most common pleural mesothelioma symptoms
Asbestos fibers are extremely thin and penetrate through the respiratory tract. At the level of the pulmonary alveoli, the inhaled particles trigger an immune response: the macrophages absorb these foreign bodies and release local cytokines and growth factors that stimulate an inflammatory reaction. This leads to the deposition of collagen and, finally, to interstitial fibrosis (asbestosis).
Asbestos fibers may also exert a direct toxic and indirectly mutagenic effect on the pleura and pulmonary tissue. The time between exposure to asbestos and the appearance of mesothelioma can be very long, in the order of a few decades.
Other factors that may predispose to the development of this neoplasm are some genetic alterations, chest irradiation and previous pulmonary infections (especially those sustained by the SV40 virus).
Further information
Mesothelioma can grow locally or metastasize to lymph nodes, heart, peritoneum, liver, and kidney. At the onset, the symptoms are rare. As the disease progresses, dyspnoea and chest pain appear, and a nodular thickening of the pleura is found. Invasion of the chest wall and involvement of neighboring structures may result in a persistent cough, fever, weight loss, sweating, hoarseness, dysphagia, paralysis of the vocal cords, abdominal pain and ascites. In most cases, there are deposits in the space between the two pleural sheets, typically monolateral, large and hemorrhagic.
Long-term survival is rare.
The assessment of mesothelioma involves a thorough medical history, with particular attention to occupational exposure to asbestos fibers, a complete physical examination and chest radiography.
Often, this tumor is difficult to diagnose and usually requires a pleural biopsy or cytological examination of the pleural fluid. Staging is performed with a chest CT scan, mediastinoscopy, and magnetic resonance imaging.
Unfortunately, pleural mesothelioma is a very aggressive malignant tumor: surgical and chemotherapeutic options have limited benefits and often do not significantly prolong survival. The main goals of therapy are pain relief and pleural effusion dyspnea by pleurodesis or pleurectomy. If the neoplasm is at an early stage, surgical resection of the tumor mass may be attempted.
4.90/5 – 1289