IMA EDB CHIKITSA SEVA RATTAN AWARD to Prof. Dr.C. K. Atal on world's first discovery and pioneering research on bioenhancer Piperine

Presented to Prof. Dr. C. K. Atal for discovery and validation of world's first bioenhancer Piperine, thereby leading to scientific validation of bioenhancers concept and consequently resulting in development of world's first bioenhanced antitubercular formulation Risorine officially released on world TB day may 2011 by Govt. of India and which was also presented to Philanthropist Mr Bill gates by the Indian Government.

 

CONTRIBUTIONS IN MEDICINE

REFERENCES-

www.jaim.in/text.asp?2010/1/2/96/65073 www.linknaturalproducts.com/downloads/lnp-digest-v6-2010-.... webcache.googleusercontent.com/search?q=cache:L5kfQKgjkMw... www.herbalnet.org/events.htm www.dailyexcelsior.com/dr-atal-conferred-edpa-award-appre...

www.flickr.com/photos/13059662@N06/13401939445/

 

 

HEALTH, MEDICINE, DRUGS, TOXICOLOGY

PHARMACOGNOSY, DRUG RESEARCH, DRUG DISCOVERY, DRUG DEVELOPMENT, NEW CONCEPTS, NEW MECHANISMS OF ACTION OF DRUGS, MEDICINAL PLANTS, AYURVEDA ETC

 

“It takes more than 10-15 years and approximately 500-600 million dollars to put a new drug into the market. Dr. Atal has provided a basket of drugs, molecules, medical concepts and novel mechanisms of action of drugs for the benefit of patients, researchers and medical community.

1.MEDICAL FRATERNITY AWARDS & HONOURS- drug research and development, medicinal plants research,–details in award section.

A.IMA AWARD- Indian Medical Association Award (IMA- EDB) Chikitsa Seva rattan (ratna) award for bioenhancers.

B.EDPA AWARD of appreciation, 2014.

C.Guest of honor at seminar on Bioenhancers jointly organized by Indian Medical Association (EDB) and East Delhi Physicians association at Delhi.

D.Inaugurated the annual conference, Hematology and blood transfusion at Govt. Medical College, Jammu.

2.OTHER AWARDS(drug development , medicinal plants)

A.Dr. I. C. Chopra Science and Technology award to Dr. Atal for several pioneering drug discoveries and drug development.

B.Professor P. N. Mehra Memorial botany award for plant sciences including work on medicinal plants.

3.AWARD WINNING RURAL HEALTH, NUTRITION, RURAL RESEARCH AND DEVELOPMENT DONE AT RRL

A.FICCI AWARD presented to RRL for rural development projects including work on rural health

B.UN GRANT for rural aquaculture development given to RRL (rural nutrition).

4.MEDICINAL CONSULTANCIES

A.World Health Organization projects in Bangladesh and USA (see toxicology).

B.UNDP projects on medicinal plants in Vietnam.

5.LITERATURE (Serial no 184-211,details in author section) -

A.World reference book on medicinal plants used globally in research institutes/universities

B.Numerous research papers in reputed national & international journals.

6.TOXICOLOGY- INTERNATIONAL AUTHORITY on Crotalaria and its Toxicity in Human Food Chain (Crotalaria Adulteration and Toxicity) and WHO / USA Consultancy

A.Solving the mysterious disease in Sarguja district, Madhya Pradesh, India as crotalaria toxicity.

B.Appointed as consultant by WHO to USA (WHO, PAHO and USFDA) as world authority on Crotalaria and toxicity in human food chain.

C.Published several serial research articles on Crotalaria.

7.PUBLIC & RURAL HEALTH- projects include successful control of external parasites (ectoparasites) like louse control using bio-antiparasitic agents , example-(1975-76) by use of Acorus calamus oil and mustard oil, Guinea worm infection (1976-77) by anti zooplankton measures like introduction of pond fishes in villages which thrive on zooplanktons. Aquaculture (rural supplementation of income and nutrition won the UN grant).

8.WORLD’S FIRST GEOTHERMAL ENERGY BORAX EXTRACTION PLANT (Puga-Ladakh-1976)- world’s highest-factory of its time, first in India and perhaps first and only example in the world to extract borax by innovative use of geothermal energy having medicinal use.

9.INDIA’S FIRST IN DRUGS AND MEDICINE

A.Breakthrough technology in mint - technology for manufacture of bolder crystals of menthol//marc into boards which is used in medical formulations.

B.Xanthotoxin manufacture from two plant sources-(ammi majus & heracleum candicans).

C.Risorine-only Indian drug from India released on world TB day, and presented by Indian government to world dignitary Mr. Bill Gates.

D.Sallaki- the second Indian “single plant based scientifically researched modern drug based on traditional Indian system”.

E.First to introduce / popularize superior imported eucalyptus macrorhynea seeds, a source of Rutin used in medicine.

F.Founder/signatory-CCRAS system of medicine.

10.DISCOVERY OF NEW MECHANISMS OF ACTION IN DRUGS

A.Bioenhancers- they increase blood levels of drug (bioavailability) and drug efficacy (bioefficacy) by inhibiting first pass metabolism and increased absorption of drug. Several more mechanisms have been studied / postulated for this effect.

B.Plant Immunomodulators from Rasayanas - first reporting in science.

11.DISCOVERY OF NOVEL OR BETTER MECHANISMS OF ACTION OF DRUGS- (Drug discovery, mechanisms of action of those drugs and first reporting in science in drugs are overlapping topics) see details in next topic and (Serial no 105-112,first reporting in science)

A.Potassium Embelate (centrally acting non narcotic orally effective analgesic acting on new undiscovered receptors in the brain).

B.Sallaki-Non steroidal anti inflammatory gastro protective plant analgesic (active ingredient Boswellic acid) working through inflammatory pathways (all other existing NSAID drugs are ulcerogenic).

C.Vasicine- bronchodilatory, oxytocic and platelet dysfunction/platelet number corrector actions.

D.Anti urolithiatic drug Debelysin (internationally marketed)-See details below.

E.RLX- Anti inflammatory cum bronchodilator drug. All other asthma drugs are either bronchodilators or else anti-inflammatory drugs.

12.WORLD’S FIRST IN BIOENHANCERS

A.Discovery of world’s first bioenhancer Piperine which is also the world’s first plant based bioenhancer. Research includes first deriving the mechanism of action.

B.First coining of the term Bioavailability enhancers (Bioenhancers).

C.This discovery was proven on world’s first experimentally bioenhanced drugs Sparteine and Vasicine.

D.Published the first scientific evidence based reference on Bioenahncers (IDMA bulletin).

E.This discovery scientifically established a new chapter in medical science.

F.Starting the first bioehnanced antitubercular project which led to development of world’s first bioenhanced antitubercular drug Risorine developed by IIIM Jammu, released by Govt. of India on world TB day 2011 and presented to Mr. Bill Gates of Microsoft.

DETAILED DESCRIPTION

DISCOVERY OF NEW CONCEPTS /FIRST REPORTINGS IN MEDICAL SCIENCE

13.DISCOVERY OF WORLD’S FIRST BIOENHANCER PIPERINE (COMMERCIALISED):

A.PIPERINE is the world’s first proven bioenhancer which was discovered and established by Dr. Atal. Spartine and Vasicine were the first experimental bioenhanced drugs, which established the world’s first bioenhancer concept (See next topic) and which ultimately led to development of world’s first bioenhanced antitubercular formulation Risorine.

B.SIGNIFICANCE OF DISCOVERY OF PIPERINE - It was the first time that a molecule was discovered which could increase the potency of several classes of existing drugs even after being administered at reduced dosed. This made the formulation more effective (bioefficacy) while dose reduction meant reduced cost of drug and reduced side effects of the drug. Prior to this the existing methods were confined to Physical methods only, like micronisation, timed release, site release formulations etc.

C.HISTORY-Bioenhancers were first scientifically documented in 1979 at RRL, Jammu. The reason for arriving at the Bioenhancer hypothesis by Dr. Atal was based on a clue on Trikatu obtained after scrutiny of Ayurvedic handbook compiled by another research institute of CSIR. He observed that a large number (about 75%) of herbal formulations used for a large variety of diseases incorporated Trikatu, or one of the ingredients of Trikatu, namely Piper longum. He posed two questions. What was piper doing in so many formulations? Is it effective against all the illnesses? Since piper cannot be a panacea, so other reasons were thought of and one likely postulation was that it probably increased the potency/ bioavailability of formulations. Further research established the bioenhancer concept. Radiolabelled Vasicine and Spartine which were already being used in other experiments at RRL, were used for bioenhancing experiments, and became the first experimental drugs in the world to be scientifically bioenhanced by Piperine in 1979 at RRL, which established the concept. Subsequently several other classes of drugs were also bioenhanced successfully, research papers were published by RRL , Piperine was patented internationally, research scholars were granted doctorate degrees on bioenhancer research and drug development project on anti tubercular formulation was initiated at RRL. With further research by others, bioavailability enhancers were renamed bioenhancers in short, because research has indicated that Piperine may increase efficacy of drugs due to mechanisms other than increased bioavailability (bioefficacy enhancer + bioavailability enhancer = bioenhancers). About 50 years earlier, Bose in his Pharmacopoea Indica while describing the antiasthmatic activity of Vasaka leaves had made an observation that addition of long pepper to Vasaka increased its efficacy. However, no explanation for this observation was put forth by anyone in science, and it remained an observation overlooked and uninvestigated for about 50 years till the discovery of bioenhancers at RRL, Jammu in 1979 based on a clue from Ayurveda.

14.ESTABLISHING NEW CHAPTER OF BIOENHANCERS IN MEDICINE-

A.NEW CHAPTER IN SCIENCE- With the discovery of Bioenhancer Piperine a new chapter in Medicine was established. The term “Bioavailability enhancers” (later renamed bioenhancers or drug boosters) was first /coined at RRL Jammu. The breakthrough was first published by Dr. Atal in 1979 in IDMA bulletin (Atal. C.K., I.D.M.A. Bull, 1979, 10, 36- “A breakthrough in Drug Bioavailability” – A clue from age old wisdom of Ayurveda”. This term did not exist anywhere in medical treatment, drug industry; textbook or scientific literature till bioavailability enhancer Piperine was discovered and authenticated.

B.SIGNIFICANCE OF DISCOVERY BIOENHANCER CONCEPT -This revolutionary award winning globally recognized breakthrough is a basic discovery which has opened new concept/chapters of Bioenhancers in science in the field of drug bioavailability. As a result, it has opened endless new molecules, drugs, classes of drugs waiting to be bioenhanced and newer bioenhancers waiting to be discovered. Several bioenhancers have been discovered after this discovery, but Piperine still remains the most potent bioenhancer till date. This is also an example of traditional drug influencing multiple classes of modern drugs, nutrients and Xenobiotics. Details are provided at the last page.

C.BENEFITS OF BIOENHANCERS- Bioenhancers act like a catalyst and make the formulations more potent even at lesser dose. Reduced dose also makes the formulation safer, cheaper, and better tolerated by patient, with lesser chance of drug resistance (due to better acceptance, better compliance and increased bioefficacy). Moreover added ecological benefits are due to reduced requirement of raw material needed for plant based drugs, particularly for “less bioavailable” plant based drugs or for rare and scarce plants, example being anti cancer drug Taxol. www.jaim.in/text.asp?2010/1/2/96/65073(J-AIM-journal). docs.google.com/viewer?a=v&q=cache:BULgW-7SSm8J:www.n... ( CSIR newsletter).

15.DRUG DEVELOPMENT PROJECT ON WORLD’ FIRST BIOENHANCED ANTITUBERCULAR DRUG - (Risorine/Kit based on Piperine officially released on World TB day, 2011)- Work was started by Dr. Atal on developing Piperine based antitubercular formulation (reference given below) keeping in mind the dire need of the society . Thereafter the world’s first Piperine bioenhanced anti tubercular formulation Risorine/Risorine kit was developed by CSIR (public private partnership) as a novel safer cheaper TB drug with fewer side effects. It was released on world Tuberculosis day 24th March 2011 in presence of current and former ministers for science and technology, India, Director General CSIR and others at Delhi, India and also presented to Mr. Bill Gates. It is almost 50 long years after which something new has happened in the field of tuberculosis research and treatment. Piperine was extensively investigated, researched and took unusually long time to get the concerned permission for launching it in market as Risorine (company launching in 2009 by Cadila Pharmaceuticals and official CSIR launching on world tuberculosis day 2011).In the meantime keletra (Lopinavir/ritonavir) was discovered and officially launched as bioenhanced antiretroviral drug(US FDA approval in 2000). Thus Risorine became the second officially marketed bioenhanced drug in world after keletra even though Rifampicin was experimentally bioenhanced much earlier. However Risorine is still the world’s first bioenhanced marketed antitubercular drug. For details of the World TB day events, See two links below. Reference- Influence of piperine on rifampicin blood levels in patients of pulmonary tuberculosis, J Assoc Physicians India. 1985 Mar; 33 (3) : 223-4 www.ncbi.nlm.nih.gov/pubmed/4044481http://pib.nic.in/news... csirindia.wordpress.com/2011/03/26/world-tuberculosis-day... RECOGNITION OF PIPERINE DISCOVERY - Bioenhancer discovery has led to the successful development of world’s first bioenhanced antitubercular drug Risorine in market.

A.Globally recognized and accepted discovery by scientific community, Wide media coverage, DD news coverage of Risorine release, internet reports.

B.Dr. I. C. Chopra award, 2000 given to Dr. Atal for plant based drug discoveries including Piperine.

C.Indian Medical Association’s Chikitsa Seva Rattan (ratna) award, IMA-EDB given to Dr. Atal for bioenhancers.

D.EDPA award of appreciation, 2014 given to Dr. Atal for bioenhancer research.

E.Many Medical Conferences on bioenhancers have been held like the one jointly conducted by Indian Medical association (EDB) and East Delhi Physician association at IMA hall (EDB) on 8th May, 2010.

F.CSIR/Govt. of India’s official launching of bioenhanced Risorine on world TB day, 2011 at Anusandhan Bhawan, Delhi.

G.Presentation of Risorine to visiting dignitary Mr. Bill Gates on world TB day, 2011.

H.IDMA research award 1981-82, discipline Pharmacology, at hotel Centaur, Mumbai (erstwhile Bombay) presented to Dr. Usha Zutshi / J. L. Kaul-on best original research paper on “The impact of Ayurvedic herbals on drug bioavailability” in Indian drugs 1982 Sep vol. 19, pg 476-79.

I.CSIR National Technology award 1993 presented to Dr. Usha Zutshi and Dr. K. L. Bedi, for work on piperine.

J.RRL Jammu alone published more than 25 research papers on Piperine based on 10 PhDs dissertations and doctorate degrees awarded on bioenhancers.

K.Worldwide recognition, research and publication of Piperine and bioenhancers.

16.DISCOVERY OF PLANT BASED IMMUNOMODULATORS (discovered from Rasayanas in Ayurveda and available as formulations in market)-First reported case of plant based immunomodulators from plant sources, discovered from Ayurvedic list of Rasayanas class of drugs, a new concept and a major contribution to science. (Serial no 17,award section-Dr. I. C. Chopra award ).Out of 16 plant drugs, 6 were studied in more detail and thus classified on the type of immune modulation produced, as immunosupressants, immunostimulants and immunocorrecting agents (immunoequiliberating). Example includes Picrorhiza kurroa that went into clinical trials has become a part of numerous modern herbal formulations. Some References - Immunomodulating agents of plant origin. I: Preliminary screening, J Ethnopharmacol. 1986 Nov; 18(2): 133 - 41. C. K. Atal, M. L. Sharma, A. Kaul, A. Khajuria, (See links below and events, CSIR, IIIM , first Dr. I. C. Chopra award)

A.http://www.ncbi.nlm.nih.gov/pubmed/3560991

B.http://www.herbalnet.org/events.htm

17.DEBELYSIN (COMMERCIALISED, INTERNATIONALLY MARKETED) patented renal antilithiatic (lithio-lytic or renal calculi dissolving drugs), based on Dolichos biflora Seeds. Not much is available in allopathic system for renal calculi, although methods exist like surgery, cystoscopic removal, lithotripsy, some uncommon methods to dissolve renal calculi, besides some herbal formulations available in market. Debelysin is a patented, safe, scientifically established drug for renal calculi with an international marketed in Poland, Byelorussia and Ukraine. Reference article -Clinical evaluation of a new antilithiatic drug," Debelysin". T Krzeski, A Borowka, W Gustowski, C.K. Atal, A. Pol J Pharmacol Pharm, 1983 - 35(1):1-6. www.ncbi.nlm.nih.gov/pubmed/6889184

18.ANTIARTHRITIC DRUG SALLAKI – BOSWELLIC ACID AS ACTIVE INGREDIENT- (COMMERCIALISED, INTERNATIONALLY MARKETED)- SECOND HERBAL DRUG IN INDIA- Apart from Rauwolfia discovered by Col. Sir R. N. Chopra in late forties, Sallaki, launched in March 1982, became the second other important scientifically proven major herbal drug based on Indian system of medicine (Ayurvedic and Unani) to formally enter Indian market in five decades post independence ( RRL newsletter April 1982). Belladonna was one more such launch elsewhere but it was not a drug in the true sense because it was launched as tincture for its non specific effects/activity on salivation and pain or else as belladonna plaster for boils which are not “activity” specific. Later Atropine extracted from Belladonna became a pure modern drug. After Rauwolfia, Sallaki was “second” in India for the following reasons. It was the second formally launched “single plant” based drug like Rauwolfia, its alcoholic extract was validated for activity in animals, activity was also established to be equivalent to crude drug, and lastly, its scientific validation in animals was reproducible (reference-Dr.K.L.Bedi). The Dr. I. C. Chopra award, 2000 was given to Dr. C. K. Atal for plant based drug discoveries particularly Sallaki, (See award section and internet link). Sallaki is also successfully marketed internationally, particularly Europe, as a safe, effective antiarthritic drug and the only non steroidal anti-inflammatory drug devoid of gastrointestinal side effects (ulceration) and instead it has gastroprotective action. www.phytomedicinejournal.com/article/S0944-7113%2808%2900... The effects on lipids were also investigated for the first time which was also done by CDRI, Lucknow, which progressed further into anti lipidaemic drug development. Mechanism of cholesterol lowering effect of Salai guggal ex. boswellia serrata roxb - U Zutshi, PG Rao, S Kaur, GB Singh, S Surjeet, CK Atal Indian Journal of Pharmacology – 1986, vol. 18,issue 3,pg 182-183.Sallaki is also reportedly being manufactured by Gufic Company in Uzbekistan and has a reported market in Russia and Europe, especially Germany. Boswellic acid is marketed by other companies like Himalaya (as Shallaki) and Amway. www.ijp-online.com/article.asp?issn=0253-7613;year=1986;v...

19.VASICINE, VASICINONE, AND ITS ANALOGUES (MARKETED AS AYURVEDIC FORMULATIONS) -OFFER OF US DOLLARS 80,000/- FOR INDO-US COLLABORATION ON THIS DRUG-exhibiting bronchodilatory, oxytocic and platelet dysfunction/platelet number corrector actions. Vasicine from Adhatoda vasica was discovered to control capillary bleeding through action on Bone Marrow. Dr. Atal while on a visit to USA in 1981 was offered Indo US collaborative research on vasicine. A provisional agreement was signed in USA with Farmacon dated 29th Oct, 1981, and agreed that the data be provided to Farmacon research Corporation, 39, South Lasalle street , Chicago Illinois, USA for a sum of US dollars eighty thousand(US $ 80,000/-) plus additional negotiable royalty , subject to CSIR Head office approval and retaining justified rights by CSIR. This was meant to be researched further in USA for possible marketing in USA (& Pakistan) as per agreement with Alan J, Schroeder, Vice President of the company. Since approval was delayed so the advance cheque was returned back to the company in USAL. This was the highest ever recorded amount of that time offered to any of the CSIR laboratories from international companies and original signed documents of agreement are still preserved. www.flickr.com/photos/13059662@N06/6506562555/in/photostream

20.RLX-a significant work on bronchodilatory effects of Deoxy vasicinone (RLX). This molecule is a wonderful anti inflammatory bronchodilator with minimal side effects as compared to conventional existing drugs and having a novel mechanism of action entirely different from others. The existing anti asthmatic drugs possesses either anti-inflammatory or else bronchodilatory effect, whereas RLX has both the properties.

21.POTASSIUM EMBELLATE-THE ONLY DRUG OF ITS KIND- a centrally acting, non narcotic orally effective analgesic, the only molecule of its kind known to exist. This is new molecule acting on so far unknown and undiscovered receptors in the brain (as peripherally it is devoid of anti-inflammatory action and centrally its effect is not reversed by opioid antagonists suggesting some different site of action/receptors in brain). Reference-

A.http://www.ncbi.nlm.nih.gov/pubmed/2561116

B.http://www.ncbi.nlm.nih.gov/pubmed/6541278

22.HEPATOPROTECTIVE FORMULATIONS (COMMERCIALISED): - significant work on plant based hepatoprotective formulations based on many plants. It was launched in the market as Livzone, a hepatoprotective formulation (Hind Chemicals, Kanpur). www.herbalnet.org/events.htm (CSIR- IIIM , Serial no 17 ,first Dr. I. C. Chopra award)

23.TECHNOLOGY TRANSFER FOR ABOVE DRUGS- Sallaki (Gufic Company, Bombay, renamed Mumbai), Hepatoprotective Livzone (Hind Chemicals, Kanpur under Dr. Rohtagi), Piperine Bioenhanced Anti tubercular formulation Risorine/risorine kit (Cadila Pharmaceuticals, Ahemedabad). Immunomodulator Picrorrhiza is being used in many herbal formulations and so is Vasicine. Antiurolithiatic drug Debelysin has been internationally developed by Herbapol from Poland.

A.DRUGS RESEARCHED IN INDIA- Sallaki, Risorine, Hepatoprotectives (Livzone), RLX, Vasicine, Potassium Embellate

B.DRUGS RESEARCHED INTERNATIONALLY- Debelysin

C.DRUGS COMMERCIALISED IN INDIA- Livzone, Risorine, Sallaki

D.INDIAN DRUG COMMERCIALISED INTERNATIONALLY- Sallaki

E.DRUGS DEVELOPED & COMMERCIALISED INTERNATIONALLY-Debelysin

24.PROCESS DEVELOPED FOR INDIA FOR SEVERAL KNOWN AND EXISTING DRUGS – Phytochemicals (Seventeen) ,Drug Intermediates (Three) ,Fermentation Technology (Four) (for detailed list Serial no 152-159,processes developed for India.Broad categories are Processes for medicinal Essential Oils Isolates(like mint), Phytochemicals, Drugs, Intermediates, Pharmaceuticals, Mineral Products(plaster of Paris), Fermentation Technology Products(citric acid),mint etc used by the Medical profession.

25.CONTRIBUTIONS IN AYURVEDA- All drugs mentioned above in drug discoveries are based on medicinal plants and Ayurvedic/herbal plants (Serial no 201-204, professional standing and peer reviews).

A.Discovery of New Drugs, Concepts and Mechanisms of Action of Drugs from Ayurveda- (Serial no 92-112, drug discovery for details).

B.Significance of Work Done, Visionary Concepts, Recognition in Ayurveda- Details in Professional Standing.

26.RENOWNED INTERNATIONAL AUTHORITY AND CONSULTANT ON MEDICINAL PLANTS (PHARMACOGNOSY)

A.United Nations Consultant-UNDP, UNIDO. USFDA,FAO,WHO Etc

B.Consultant - International World Bodies, Universities, Organisations Etc

27. LISTED AMONG TOPMOST INDIAN PIONEER MEDICINAL PLANTS RESEARCHERS AND THINKERS IN NATIONAL JOURNALS

A.CURRENT-SCIENCE Ayurveda-scientific research and publications, NO-97, VOL-8/25-10-2009.

B.CURRENT SCIENCE -The quest for evidence based Ayurveda: lessons learned, VOL. 102, NO. 10, 25 MAY 2012.

C.J-AIM - A Renaissance for Ayurveda, J. Ayurveda. Integr Med. 2010 Jan-Mar; 1(1): 1–2.

28.LISTED AMONG TOPMOST PIONEER INTERNATIONAL RESEARCHERS IN INTERNATIONAL JOURNAL

A.CELEBRATED RESEARCHERS: SERIAL -7, Link natural products digest, vol. 6 issue 2, 2010, pg13.

29.UNITED NATIONS PROJECTS IMPLEMENTED INTERNATIONALLY

A.UNDP/UNIDO- HERBAL MEDICINES (VIETNAM).

B.WHO- BANGLADESH-MEDICINAL FORMULATIONS FOR GOVT OF BANGLADESH.

C.WHO- USA- CONSULTANCIES ALL OVER USA ON PLANT TOXICITY IN HUMAN FOODCHAIN.

30.BOOK RELEASED AT INDIAN PHARMACEUTICAL CONGRESS (IPC-DELHI-2008)-"HIV, Aids & Bioactive Natural Products” at event diamond jubilee celebrations).

31.MEDIA COVERAGE - Risorine release covered on DD news channel, borax plant covered on BBC news, medicinal awards in news, internet etc

 

Done