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Phylogenetic analysis of vertebrate dopamine receptors of the D2-family.The distant tree was built with the neighbor-joining algorithm from alignments of the D2, D3 and D4 receptor subtypes from several vertebrate species. Data were re-sampled by 1000 bootstrap replicates to determine confidence indices within the phylogenetic tree. The scale bar refers to a phylogenetic distance of 0.09 amino acid substitution per site. The different vertebrate classes are indicated by different colors (mammals, blue; birds, dark green; reptiles, light green; amphibians, brown; fish, red; cyclostomes, mauve). GenBank accession numbers of the sequences are: Homo sapiens D2, AAA52761; Macaca mulatta D2, XP_001085571; Bos taurus D2, DAA22356; Canis lupus familiaris D2, AAG34494; Mus musculus D2, NP_034207; Rattus norvegicus D2, NP_036679; Gallus gallus D2, NP_001106761; Meleagris gallopavo D2, AAD03818; Anoils carolinensis D2, XP_ 003217484; Xenopus tropicalis D2, XP_002937871; Xenopus laevis D2, CAA51412; Rana catesbeiana D2, BAI70438; Mugil cephalus D2, AAU87970; Oreochromis niloticus D2, AAU87971; Tetraodon nigroviridis D2, CAF97490 ; Oncorhynchus mykiss D2, CAC87873; Danio rerio D2a, AAN87174; Danio rerio D2b, AAP94011; Anguilla anguilla D2A, ABH06893; Anguilla anguilla D2B, ABH06894; Lampetra fluviatilis D2, ADO23655; Mus musculus D3, 2105315A; Rattus norvegicus D3, 1614344A; Canis lupus familiaris D3, XP_545106; Homo sapiens D3, 1705199A ; Bos taurus D3, NP_001179824; Carassius auratus D3, ABN70936; Danio rerio D3, AAN87173; Homo sapiens D4, 1709359A; Macaca mulatta D4, XP_001087197; Mus musculus D4, 2109259A; Rattus norvegicus D4, AAA18588; Danio rerio D4a, AAW80614; Danio rerio D4b, AAW80615; Danio rerio D4c, AAW80616.

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