Operation UNITE (Unlawful Narcotics Investigations, Treatment and Education) was created in 2003 by U.S. Congressman Harold “Hal” Rogers (KY-5th) to provide a regional, community-based anti-drug response to the prescription drug epidemic sweeping across southern and eastern Kentucky. Serving a 33-county region, UNITE is engaged in numerous education, treatment and law enforcement initiatives – many with state and federal partners – designed to empower citizens groups and community leaders to no longer accept or tolerate the drug culture. This is achieved through expanding youth-focused anti-drug prevention and education programs, community campaigns about the dangers of drugs, coordinating treatment, recovery, and outreach programs for those struggling with a substance use disorder, providing support to families and friends of substance abusers, and conducting undercover narcotics investigations. UNITE also advocates for changes in state and national legislation aimed at curbing substance misuse and diversion. UNITE's programs have been heralded at many levels, including the White House. Additionally, UNITE created and now serves as Educational Advisor for the annual Rx and Illicit Drug Summit – the largest national collaboration of professionals from local, state, and federal agencies, businesses, academia, clinicians, treatment providers, counselors, educators, state and national leaders, and advocates impacted by prescription drug and heroin abuse. UNITE also staffs and operates the KY HELP Statewide Call Center - 1-8338-KY-HELP (1-833-859-4357) - which provides resources to those impacted by substance use, either personally or within their family and friends.