The LifeCycle Organisation was founded in 1999 to create awareness and generate support for patients suffering from end stage renal disease.

To do this it organizes the LifeCycle Challenge, which is one of the most gruelling endurance events in Europe, pitting a dedicated team of Maltese cyclists against the elements in a long distance ride through different countries all over the world. This event covers an average of 2,000km in a mere 10 days and is held annually in the summer months.