The Klahoose First Nation is a First Nations government located on Cortes Island at the northern end of the Strait of Georgia, and surrounding Toba Inlet, in southwestern British Columbia, Canada. The Klahoose are part of, with their neighbours the Sliammon, Homalco, whose territory is on the mainland and K'omoks, the larger grouping of the Comox people, which is a subgroup of the Coast Salish. The ancestral tongue is the Comox language.

The Klahoose First Nation is a member government of the Naut'sa mawt Tribal Council (NmTC).