Born in Toronto, the artist attended the Ontario College of Art and Design (OCAD) and studied Fine Art Drawing and painting, receiving the George A Reid award for painting. Subsequent to that the artist attended the Toronto School of Art as well as Seneca College studying computer animation. After OCAD the artist became represented by XEXE gallery in Toronto later known as KWT Contemporary. Bryn’s oil paintings are collected internationally. In 2007 Bryn became interested in creating immersive environments in virtual reality spaces as a new media artist known as Bryn Oh. Since then Bryn's work has featured in magazines such as Vogue, in movies and in galleries and museums worldwide.

Exhibitions include the Jewish museum in Berlin with European director Peter Greenaway and Saskia Boddeke, Manege Museum in Moscow, Russia, "Danse Macabre" with Peter Greenaway in Basel, Switzerland, the 17th Biennial of Cerveira, World Expo in Shanghai (Spanish pavilion) Nuit Blanche in Toronto and others. Bryn's work is part of the curriculum for several colleges and universities with a new course on Bryn’s work at York University. Bryn has received four new media grants from the Ontario Arts Council with the latest being in February of 2019.

Bryn Oh also created a virtual environment to help heal soldiers with PTSD (post traumatic stress disorder) as a commission for the United States military.

My artistic focus is in the way modern society is affected by technology, ranging between human/machine and machine/machine relationships. Often we consider technology to open channels for people to interact and engage socially, however, the opposite can occur where people become isolated within their own personal bubble, separate and witnessing the world from a distance almost as a product with brittle popularity. My work expresses a yearning for meaningful connections within the new technological realm that often contains human remoteness. I build virtual reality environments that convey the juxtapositions between human emotion and machine sentience. I combine poetry with a melancholy narrative that explores the themes of connection and belonging.