Only by investing fully in prevention can we provide everyone with affordable, good quality care that guarantees equal opportunity to enjoy a healthy life. It is this thinking that led to the formation of the Institute for Preventive Health (i4PH), part of an alliance between TU Eindhoven, Wageningen University & Research, Utrecht University and UMC Utrecht. Using an integral perspective, i4PH is building on and further developing existing multidisciplinary research, and innovative interdisciplinary education, at the intersection of lifestyle, environment and technology.