The University is situated approximately on a sixteen square-kilometre campus of undulating land and pleasant surroundings, about seven kilometres away from the central business district of the city of Kumasi. The campus presents a panorama of beautiful and modern buildings interspersed with verdant lawns and tropical flora, which provide a cool and refreshing atmosphere congenial to academic studies. It has within the short period of its existence become an important centre for the training of scientists and technologists not only for Ghana, but also for other African countries as well as from other parts of the world.

There are six Halls of residence and a number of hostels in the University. They are Queen Elizabeth II, Unity, Independence, Republic, University, and Africa. Three of the Halls of residence are mixed, two for males only and one for females only. Of the five hostels, two are for postgraduate students, one for both undergraduate and graduate students and managed by the Ghana Universities Staff Superannuation Scheme (GUSSS).