Isolated respiratory structures in a mouse embryo
The image represents the whole mount immunofluorescent staining for cytokeratin 8 in a mouse embryo at embryonic day 11.5. It shows a position of the respiratory structures ventrally in relation to the esophagus dorsally at early stages of the larynx formation. By the time the larynx initiates its development the trachea is already separated from the esophagus and branches into two lung lobes. The lateral walls of the primitive larynx fuse at midline and block the entrance into lower airway structures. This connection is eventually disintegrated and vocal folds separate from each other. Failure in the vocal fold separation leads to the congenital laryngeal disorders, such as laryngeal webs or stenosis.
This image was chosen as a winner of the 2016 NIH funded research image call.
This image is not owned by the NIH. It is shared with the public under license. If you have a question about using or reproducing this image, please contact the creator listed in the credits. All rights to the work remain with the original creator.
Credit: Vlasta Lungova, Thibeault lab, Department of Surgery, Division of Otolaryngology Head and Neck Surgery. UW Madison
NIH funding from: National Institute on Deafness and Other Communication Disorders (NIDCD)
Isolated respiratory structures in a mouse embryo
The image represents the whole mount immunofluorescent staining for cytokeratin 8 in a mouse embryo at embryonic day 11.5. It shows a position of the respiratory structures ventrally in relation to the esophagus dorsally at early stages of the larynx formation. By the time the larynx initiates its development the trachea is already separated from the esophagus and branches into two lung lobes. The lateral walls of the primitive larynx fuse at midline and block the entrance into lower airway structures. This connection is eventually disintegrated and vocal folds separate from each other. Failure in the vocal fold separation leads to the congenital laryngeal disorders, such as laryngeal webs or stenosis.
This image was chosen as a winner of the 2016 NIH funded research image call.
This image is not owned by the NIH. It is shared with the public under license. If you have a question about using or reproducing this image, please contact the creator listed in the credits. All rights to the work remain with the original creator.
Credit: Vlasta Lungova, Thibeault lab, Department of Surgery, Division of Otolaryngology Head and Neck Surgery. UW Madison
NIH funding from: National Institute on Deafness and Other Communication Disorders (NIDCD)