Taiwan National health research institute in accordance to the birds and beasts flu correlation research and development progress explanation

www.nhri.org.tw/nhri6/enews.php

 

facing the imminent birds and beasts flu crisis, the national health research institute studies the team in Chair Wu's under the existing writing leadership, by clinical research group Director Su Ijen group, the vaccine researches and develops Zhongxinzhuang again Director Cheng, the biological technology and medicine research group Director Zhao Yu fresh group, vice- researcher summer Keshan and its the research team, separately in the country in accordance to in the strategy, the gram flu manufacture and the vaccine research and development unites the strength, controls the bureau from June and the Executive Yuan health bureau disease to build up domestic and foreign from all walks of life outstanding people 20 person of tenable "the Taiwan flu research team", joins together by country Wei Yuan establishes it "the flu to study the special case plan", July Southeast Asia epidemic disease area inspection, August global flu seminar, September gram flu medicine simulation and the vaccine factory breaks ground, so that recently for the correlation policy explanation could, the time the entire society to the birds and beasts flu in accordance to the guidance correct path.

 

The birds and beasts flu threat in under the World Health Organization's warning, next year (2,006) 1 to March will be the most essential observation time, for will be able soon in accordance to this not to be possible the careless and indiscreet flu question, to purchase the gram flu medicine in our country to have under the difficulty, will decide by the people strength breakthrough 萬難. This June disease controls the bureau set domestic and foreign correlations domain expert to establish the research team, draws up together 周延 the flu studies the special case plan. On June 22 in presides over the anti- flu with illness administrative bureau which convenes to study in together the plan conformity discussion conference, namely the resolution is responsible by country Wei Yuan to study feasibility of the domestic self-made anti- flu medicine, country Wei Yuan begins to study of chemical synthesis step immediately the gram flu. Late August the country peaceful conference based on the national guard demand, for defends the people safety, instructed this courtyard as fast as possible researches and develops a gram flu. Meanwhile by health bureau official instruction and request country Wei Yuan and system of regulation and production feasibility merchant cooperation research gram flu medicine.

 

After at the beginning of July country Wei Yuan and illness administrative bureau pass through discusses in every way, decided composes a Southeast Asia birds and beasts flu to inquire the research team, and forms a line visiting on July 26 and H5N1 experienced Hong Kong, Vietnam, and Thailand and so on three national academic organizations. This line of main goals are clarifying several to face, first was understanding the H5N1 virus the laboratory diagnosis and virus's evolution, second is clarifying patient's clinical manifestation, the laboratory each inspection characteristic and the treatment, third is learning or ascertain on the spot four examples H5N1 pathological anatomy discovery, determines the H5N1 flu the immunity pathology and the high mortality rate reason; Finally also was understanding the H5N1 popular present situation and the various countries' government prepares situation.

 

Hong Kong was in 1997 the H5N1 first popular country, in 18 case of illness, some 6 examples death, two examples accepted the dissection. Hong Kong Chinese university's pathology Professor Dr. Ka-Fai To had reported the H5N1 patient's main cause of death is the cell hormone storm (cytokine storm) and the viral correlation bites the blood syndrome (hemophagocytic syndrome). This discovery obtains the confirmation at the afterwards Vietnamese case of illness and in Thailand's dissection example. The clinical on performance except has a fever, outside the cough, has the very high ratio (40-60%) to have the diarrhea. Thai Doctor Mahidol university's pathology Mangkol Uipraserktkul, Thai medical department's Supamit Chunsuttiwat, as well as in Professor Pilaipan together research discovered that, the virus may duplicates in the lung and the intestines, may explain the H5N1 virus is a whole body infection, also the symptom serious and the viral quantity is related.

 

On August 12, on 13th the country health courtyard holds the global flu popular academic seminar, the invitation overseas to the H5N1 experienced scholar including Hong Kong Chinese university's Dr. Ka-Fai To, Japanese state-run infection sickness NIID Dr. Takato Odagiri, Thai MOPH-US CDC Dr. Sonja J. Olsen and Vietnamese Ho Chi Minh city Oxford University research center Dr. Menno D. de Jong and so on comes to participate in the discussion together, hoped can strengthen Taiwan in this aspect preventing and controlling, in particular the flu and the H5N1 birds and beasts flu clinical attribute, a viral type 鑑 decide and evolved, the immunity pathology research, the medicine treatment, the vaccine research and development and the epidemiology forecast and so on.

 

After this conference discussion, the country health courtyard has drawn up the futurology work key point, is responsible by the clinical research group to study H5N1 the pathology to have and the immunity pathogenesis, and according to this direction formulation flu patient clinical treatment mutual recognition criterion, prepares when the flu occurs, in treats on the patient to have relies on. In addition, grinds the group by the fresh technique medicine to train the disease-resistant poisonous medicine in advance the system regulation, prepares urgently when in domestic pharmaceutical factory manufacture. The vaccine research and development center then will conduct the H5N1 vaccine research and the preparation. In addition, country Wei Yuan also will coordinate the disease to control the bureau the preventing and controlling policy, will assist the viral monitor, the viral diagnosis, to hold the seminar and the assistance policy formulation.

 

At the end of August the country health courtyard starts to the laboratory trains system of regulation the gram flu, the gram flu medicine "the shikimic acid" shikimic the acid synthesis altogether needed 12 steps and the system regulation from the outset, the summer Keshan vice- researcher and its the research team has used 羅氏 12th the steps and the system regulation pharmaceutical factory improvement, but remoew the use triazo-compound to the sixth step (azide) in order to avoid eliminated the possible laboratory danger, causes the experiment to carry on smoothly, at present country Wei Yuan is responsible for the small scale synthesis step research and development work smoothly to complete to at the end of September, and trained system of regulation after the laboratory purifies makes 20 male gram gram flu, The purity is bigger than 99 ﹪ above. For in accordance to has when the birds and beasts flu the need more gram flu medicine, at present already by in the government and the original factory discussion, strives for the authorized agreement domestic self-restraint, future when national urgent need, will utilize the gram flu synthesis and the system regulation research and development technology, domestic will carry on the gram flu medicine by the health bureau prompt start the mass productions, will maintain the national safety.

 

Blocks the virus and take protects the most majority the public safely as the guard policy biggest consideration, but this strategy picks the line most to need the supine 賴克 flu medicine the effect and the populace can effectively operate underneath the hygienic custom and the circular transparent mutual recognition, the gram flu medicine besides the treatment birds and beasts flu patient, regarding reduces the viral quantity with to prevent the viral proliferation acting quite important role, therefore as fast as possible assists to complete a gram flu the quantity to produce the work to be supposed to be this courtyard urgent matter.

"Article: Depends 瑨 Tawny daylily, Zhu Hsiaowen; Photography: Shen Shihhua; Chart one: Chair Wu existing writing (center), Director Su Ijen group (left) and the summer Keshan vice- researcher (is right) to the media explanation medicine research and development process; Chart two: In the courtyard studies business office Department Head Zhang Zhongming to say the ming dynasty printed books courtyard research and the duty; Chart three: 8,/12 Yu Chuna holds the global flu popular academic seminar "

 

 

The courtyard serves Ji Shih

The country health courtyard experimental animal center begins using

 

The country health courtyard experimental animal center establishment to studies the building, the area is 6,830 square meters (2,066 level ground), the primary area divides into the micro-organism raising area, the infection animal feed area, the rabbit, the dog, miniature 猪 Raising area and so on.

 

In the near future for will raise (generation) in accordance to this courtyard colleague to the experimental animal to raise the demand, and the consideration animal center overall project progress, transport business will plan general to pick the stage to carry on. First the animal center will carry out the temporary few partial operations, will use the region initial period only to be restricted in the dog area, the related transport business matters concerned showed already Yu Penyuan south the bamboo the courtyard area will conduct "the experimental animal center temporary few partial operations explanation on October 17 to be able", will be able to hit generatrix of plan in view of this operation, uses the region and the correlation standard operation sequence (SOP) and so on carries on the explanation; For strengthens the colleague in addition to environment familiar, meets 後動 the central personnel also in turn to lead the colleague really to visit the location, and (SOP) carries on according to the correlation standard operation sequence trains.

 

In view of the fact that the experimental animal holds the extremely important role in the support foundation and the clinical 整合性 research, but experimental animal and the animal center quality of quality good 窳 more direct influence research results, therefore the future experimental animal center because researcher's use will demonstrate its value, but the environment maintenance will be all users' responsibility, the animal center future also provides higher quality and a specialized service.

"Article: Open 淑美; Photography: Shen Shihhua; Chart: The participation explained can the colleague to enter in front of the animal feed area to test the clothes according to the standard operation sequence "

 

 

Conference report

"Center Australian biology information seminar" Australia-Taiwan Bioinformatics Symposium 2,005

 

"Center the Australian biology information seminar" (Australia-Taiwan Bioinformatics Symposium 2,005) is Australian Australian Research Council (ARC) Centre in Bioinformatics (is called ACB) bilateral academic exchange which consults with our country biology information scholar conducts. This year the conference has arranged and the gene group compares the research including the gene body study (Genomics and Genome Comparison), the biological information the function gene body study application of in (Bioinformatics in Functional Genomics), the protein 質體 study (Proteomics), the structure biology information study (Structural Bioinformatics), the protein correlation (Protein Interactions) and so on the subject, makes the lecture by the bilateral scholars, the exchange research attainment, and arranges the Australian scholar senate to visit the domestic biological information center, hoped the affiliation by promotes each other in the biological information domain research understanding, surges the common research sign, develops the concrete cooperation plan.

 

In this year the Australian biology information seminar the vacation state-run Qinghua University life academy of science lecture hall conducts from September 6 to 7th, altogether attracts 94 people to participate, scene interaction situation extremely enthusiastically.

 

The seminar first introduction uses High-throughput bioinformatics by Dr. Mark the Ragan the method, may automate carries on 144 kind of nuclei biology gene body compared to analyzes, compared to 22,437 family 422,971 kind of protein, makes the evolved tree, discussion nucleus biology lateral gene transfer (LGT) the phenomenon, and finds the gene donor and recipient, to in the region are more massive than processing experience in the designation gene body, quite has the reference value. Moreover, yellow is well-versed in the classics professor to introduce the GAINER analysis tool, mainly uses for to seek protein motif, this is quite practical research regarding the protein function; Professor Yang Yongcheng introduced seeks the pathogenesis gene using the bioinformatics way the method, for example (SCA) center discovers trinucleotide repeats and the disease serious degree connection in hereditary spinal cord cerebellum movement dysaynergia Spinocerebellar Ataxia, therefore may seek other disease genes using trinucleotide repeats which possibly exists.

 

Dr. Phoebe Chen introduced how effective carries on the information conformity in the quantity multitudinous gene body information, the affiliation 模組 recognizes (pattern recognition) by the sequence and the material exploration method analyzes the gene body information. Dr. Chen succeeds use pattern recognition, compared to will operate makes the power of exponent the reduction, will cause genome data compared to reduce to the time, is been profound the person impression. Professor Sun Hsiaofang introduced discusses short repetition sequence LCRs (Low copy repeats) on the Genome distribution, seeks the pathogenesis gene. Professor Sun uses the scan, in search gene body sequence short redundant sequence LCRs, finds on human chromosome 22q11 with DiGeorge/velocardiofacial syndromes related LCRs, and develops the PCR method, may accurately examine this heredity disease in the short time. Professor Lu Pingkiang introduced in addition Genome Profile DataBase the application, it may assist the researcher fast to understand Genome Profile the basic information, also can carry on the 2D-gel hypothesized protein electricity to swim the analysis. This courtyard research resources place Zhang Ishou Department Head Yu Tz'utz'u in the seminar introduced the penetration by the Bayes regression method, carries on array-CGH DNA micro array material processing and the analysis, the affiliation is enhancing the signal to obtain the more suitable analysis result.

 

Dr. Pablo Moscato has brought in addition take the breast cancer as the example explanation, the affiliation by the biological information study analysis 異質性 disease way, establishes from Oncogene to the Oncosystem pattern introduction, arouses the attending personnel's interest. In addition, Professor Jiang Junghsien explained affiliation from network cluster and classification gene ontology, in view of protein between correlation, has established the automated function 模組 search method.

 

The seminar second day agenda, by Dr. Martin Frith is the people in attendance introduced studies interesting and non- standard type transcripts using the computer exploration way, understood they in the gene body role of the acting, the content brilliant rich also are interesting. In future, Professor Xu Wenlien explained assigns skeleton of using the NMR analysis protein structure when meets the question, and proposed RIBRA and GANA develop the algorithm to improve. Conference final, then professor has just published utilization discussion protein entropy and the hydrogen exchange relations by Huang Zhen, discovered local structural stability and structure conservation was related, therefore protein sequence structure entropy, may use for further to understand between the protein sequence and the structure relations.

 

In a day half seminar, Australian and the Taiwan both sides scholar warmly discusses, and fully exchanges attainment of the respective research. After the meeting and arranges the Australian people in attendance to carry on the senate to visit the activity, lets the Australian scholar expert to the Taiwan biology information domain development, some thorough understanding, for both sides future the further cooperation, will lay the good foundation.

"Article: Wang Shihhai; Chart: All people in attendance group photo, Qinghua University life academy of science provides "

 

 

Academic activity

Vaccine research and development center education and training -- Project Management For Biotechnology

 

 

Curriculum subject: Project Management For Biotechnology

Lecturing: Dr. Pele Chong (Director, Vaccine R&D Center)

Time: 9:00-10:00 a.m.

Place: R1-B1222, Research Building I, Zhunan Campus, NHRI

 

The date and speaks the topic:

1.11/04 Creating Project Profile

2.11/11 Initiate Project Management

3.11/18 The Concepts of Matrix Systems and Platform

Technology

4.11/25 Define the Roles of Project Sponsor and Project

Leader (manager)

5.12/02 Define the Roles of Project Team, Project Members

6.12/09 Define Milestones and Deliverables with Time, Cost and Quality (TCQ)

7.12/16 Risk Management

8.12/23 Project Termination Processes

9. 1,/06 Case Study, Q & A

 

Welcome to participate enthusiastically! (For example will have 異動 separate informs)

"Article: Zhan Shao Xian; Photography: Cao Ching; Chart: 10,/21 curriculum Overview of Project Management "

 

 

Done