Ω CONOTOXIN GVIA

www.difficultpeptide.com/products/conotoxin-gvia/

Ca2+ channel blocker (N-type), Synthetic toxin originally isolated from Conus geographus. Specific blocker of Cav2.2 (N-type) Ca2+ channels. Binds to the Cav2.2α1 subunit (α1B) and its action is only partially reversible.

 

SPECIFICATION OF Ω CONOTOXIN GVIA

Product Name: ω-conotoxin GVIA (omega-Conotoxin GVIA, Ca2+ channel blocker (N type))

CAT.#: C1030-V

 

CAS N0.: 106375-28-4

Sequence: CKSXGSSCSXTSYNCCRSCNXYTKRCY (Modifications: C-terminal amide; X-4 = Hyp; X-10 = Hyp; X-21 = Hyp; Disulfide bonds: 1-16, 8-19, 15-26)

Purity: > 96%

Solubility: Soluble in water

Form/State: Lyophilized powder

Molecular weight: 3037.40

Molecular formula: C120H182N38O43S6

Source: Synthetic peptide

Shipping and storage: Shipped at room temperature. The product, as supplied, can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.

Storage of solutions: Up to two weeks at 4°C or three months at -20°C.

 

APPLICATION OF Ω CONOTOXIN GVIA

ω-conotoxin GVIA is a 27-amino acid peptide isolated from the venom of the marine cone snail Conus geographus, which specifically inhibits CaV2.2, are promising scaffolds for novel analgesic.

 

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