rcpt_sys_ACH_esterase

www.cnsforum.com/imagebank/item/rcpt_sys_ACH_esterase/def...

 

www.cnsforum.com/content/pictures/imagebank/hirespng/rcpt...

 

changturtle.blogspot.com/2010/03/blog-post_20.html

 

The mechanism of action of acetylcholinesterase

 

Cholinergic nerve transmission is terminated by the enzyme acetylcholinesterase (AchE). AchE is found both on the post-synaptic membrane of cholinergic synapses and in other tissues eg red blood cells. Acetylcholine (Ach) binds to AchE and is hydrolysed to acetate and choline. This inactivates the Ach and the nerve impulse is halted. AchE inhibitors (eg rivastigmine) prevent the hydrolysis of Ach, which increases the concentration of Ach in the synaptic cleft; AchE inhibitors are widely used in the treatment of Alzheimer’s disease.

 

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introduction to autonomic pharmacology. In: Basic and clinical pharmacology, 8th edition. Katzung BG. USA: The McGraw Hill Companies, Inc, 2001:75–91.

 

The Lundbeck Institute

CVR-nr. 56759913

©Copyright 2002-2005

All Rights Reserved

 

www.nature.com/nrn/journal/v2/n4/fig_tab/nrn0401_294a_F1....

 

藥物治療

以乙醯膽鹼酯酶抑制劑為最重要的治療方案

目前高醫神經科提供的藥物治療選擇包括

 

愛憶欣 Donepezil ( Aricept)

憶思能 Rivasrigmine ( Exelon)

利憶靈 Galantamine ( Reminyl )

(三者都需要健保專案核可才能使用)

 

阿茲海默氏症治療藥品 健保使用規範

 

乙醯膽鹼酯酶抑制劑的作用機轉

 

抑制乙醯膽鹼酯酶水解乙醯膽鹼的作用,進而增加乙醯膽鹼之濃度，無法逆轉失智症進展的過程，只能幫助延緩病程的進展及在認知行為表徵上得到改善

 

乙醯膽鹼酯酶抑制劑的副作用

包括噁心 ‧嘔吐‧ 胃絞痛‧腹瀉‧食慾減退‧眩暈，如果出現這些副作用，請跟您的主治醫師討論。

Done